Letter to the Editor: Decoding intrahepatic cholangiocarcinoma through lactate metabolism - from cellular states to therapeutic targets

doi:10.3748/wjg.118233

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Aug 7, 2026; 32(29): 118233
Published online Aug 7, 2026. doi: 10.3748/wjg.118233

Letter to the Editor: Decoding intrahepatic cholangiocarcinoma through lactate metabolism - from cellular states to therapeutic targets

Yasser Fouad, Ahmed Gomaa, Gamal Esmat

Yasser Fouad, Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine, Minia University, Minia 19111, Egypt

Ahmed Gomaa, Department of Gastroenterology and Endemic Medicine, Fayoum University, Fayoum 19777, Egypt

Gamal Esmat, Department of Endemic Medicine and Hepatogastroenterology, Cairo University, Cairo 11562, Egypt

Gamal Esmat, Department of Research, Badr University, Cairo 12342, Egypt

Author contributions: Fouad Y conceptualised the idea; Fouad Y, Gomaa A, and Esmat G wrote and revised the manuscript.

Conflict-of-interest statement: All authors declared no conflict of interest.

Corresponding author: Yasser Fouad, MD, Professor, Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine, Minia University, El-Horria Street, Minia 19111, Egypt. yasser.abdallah@mu.edu.eg

Received: December 30, 2025
Revised: February 5, 2026
Accepted: February 12, 2026
Published online: August 7, 2026
Processing time: 202 Days and 13.7 Hours

Core Tip

Core Tip: Lactate metabolism organises intrahepatic cholangiocarcinoma heterogeneity, linking metabolic activity to cellular hierarchy, mitochondrial function, and immune evasion, offering new avenues for stratification and therapy.