Diagnostic efficacy of fecal calprotectin combined with a high-sensitivity quantitative fecal immunochemical test for colorectal tumors
Wei Jing, Lei Qin, Xiao-Han Zhang, Fei Pan, Rong-Rong Ren, Yan Li, Yan Zhang, Li-Hua Peng, Zi-Kai Wang, Xiu-Li Zhang
Wei Jing, Lei Qin, Xiao-Han Zhang, Fei Pan, Rong-Rong Ren, Yan Li, Yan Zhang, Li-Hua Peng, Zi-Kai Wang, Xiu-Li Zhang, Microbiota Division, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, Beijing 100853, China
Wei Jing, Xiao-Han Zhang, Fei Pan, Li-Hua Peng, Zi-Kai Wang, Xiu-Li Zhang, School of Medicine, Nankai University, Tianjin 300071, China
Co-first authors: Wei Jing and Lei Qin.
Author contributions: Jing W and Qin L contributed equally to this work, as co-first authors; Jing W, Qin L, and Zhang XL were responsible for the study design; Jing W was responsible for data analysis and writing of the original draft; Qin L was responsible for data collection and curation, and writing of the original draft; Zhang XH, Pan F, Ren RR, Li Y, and Zhang Y carried out the study implementation; Peng LH and Wang ZK provided reagents; all authors have read and approved the final manuscript.
AI contribution statement: The authors take full responsibility and accountability for all content of this manuscript, including any portions for which AI tools were used as assistive technologies. All AI-assisted outputs were carefully reviewed, validated, and approved by the authors. AI tools were not used to generate original scientific data, perform independent scientific analyses, or draw scientific conclusions.
Institutional review board statement: This study was approved by the Ethics Committee of the First Medical Center of Chinese People’s Liberation Army General Hospital, No. S2025-886-01.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: No additional data are available.
Corresponding author: Xiu-Li Zhang, MD, Chief, Microbiota Division, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese People’s Liberation Army (PLA) General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.
zhangxl70@126.com
Received: March 20, 2026
Revised: June 2, 2026
Accepted: June 22, 2026
Published online: July 28, 2026
Processing time: 114 Days and 14.9 Hours
