Letter to the Editor: Hepatocellular carcinoma in patients without cirrhosis - urgent need to include Australasian populations

doi:10.3748/wjg.117785

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 28, 2026; 32(28): 117785
Published online Jul 28, 2026. doi: 10.3748/wjg.117785

Letter to the Editor: Hepatocellular carcinoma in patients without cirrhosis - urgent need to include Australasian populations

Aparna Morgan, Angela Zhu, Nicholas Hannah, James Haridy, Ashok Raj, Neeraj Bhala

Aparna Morgan, Angela Zhu, Nicholas Hannah, James Haridy, Ashok Raj, Neeraj Bhala, Department of Gastroenterology and Hepatology, Royal Melbourne Hospital & The University of Melbourne, Melbourne 3050, Victoria, Australia

Author contributions: Morgan A, Zhu A, Hannah N, Haridy J, Raj A, and Bhala N were involved in the research work and contributed to the writing, reviewing and editing of this manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Neeraj Bhala, PhD, Professor, Department of Gastroenterology and Hepatology, Royal Melbourne Hospital & The University of Melbourne, 300 Grattan St, Parkville, Melbourne 3050, Victoria, Australia. neeraj.bhala@mh.org.au

Received: December 17, 2025
Revised: January 20, 2026
Accepted: January 29, 2026
Published online: July 28, 2026
Processing time: 204 Days and 14.9 Hours

Core Tip

Core Tip: Global reviews of hepatocellular carcinoma (HCC) that exclude Australasian data risk overlooking important epidemiological patterns. In Australia and New Zealand, non-cirrhotic HCC accounts for a substantial proportion of cases, driven predominantly by chronic hepatitis B and an increasing burden of metabolic dysfunction-associated steatotic liver disease, particularly among Indigenous and migrant populations. Inclusion of Australasian data is essential for a truly comprehensive understanding of non-cirrhotic HCC risk and surveillance worldwide.