Letter to the Editor: Origin recognition complex subunit 1 as a biomarker in hepatitis B virus-related hepatocellular carcinoma: Promises and pitfalls

doi:10.3748/wjg.117508

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jul 14, 2026; 32(26): 117508
Published online Jul 14, 2026. doi: 10.3748/wjg.117508

Letter to the Editor: Origin recognition complex subunit 1 as a biomarker in hepatitis B virus-related hepatocellular carcinoma: Promises and pitfalls

Gong-Zheng Wang, Xin-Ya Zhao, Xi-Ming Wang, Lian-Bang Wang

Lian-Bang Wang, Xi-Ming Wang, Xin-Ya Zhao, Gong-Zheng Wang, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China

Co-corresponding authors: Xin-Ya Zhao and Gong-Zheng Wang.

Author contributions: Wang LB wrote the original draft; Wang GZ and Zhao XY contributed to conceptualization, writing, reviewing and editing, and contributed equally as co-corresponding authors; Wang GZ and Wang XM participated in drafting the manuscript; All authors have read and approved the final version of the manuscript.

AI contribution statement: The entire main text was written exclusively by the authors. No generative AI was used to create any part of the text. Only ChatGPT was used for language polishing. All final wording was decided by the authors.

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Corresponding author: Gong-Zheng Wang, MD, PhD, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Jinan 250021, Shandong Province, China. wanggz0322@163.com

Received: December 9, 2025
Revised: January 6, 2026
Accepted: February 3, 2026
Published online: July 14, 2026
Processing time: 200 Days and 1.7 Hours

Core Tip

Core Tip: Serum origin recognition complex subunit 1 has emerged as a potential biomarker for hepatitis B virus-related hepatocellular carcinoma, which improves diagnostic accuracy when combined with extra spindle pole bodies-like 1 and alpha-fetoprotein. These indicators may eventually be integrated into a unified surveillance model to enhance early detection. Large, multicenter prospective studies and standardized assay development are essential to confirm its applicability across diverse clinical settings.