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World J Gastroenterol. Jul 7, 2026; 32(25): 118597
Published online Jul 7, 2026. doi: 10.3748/wjg.118597
Published online Jul 7, 2026. doi: 10.3748/wjg.118597
Calcium-dependent signaling protein family member S100A11 promotes liver and adipose lipid accumulation through fibroblast growth factor 21
Qian-Qian Zhang, Xiao-Qing Lu, Yu-Xin Jin, Jing-Yan Han, Yin Li, Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China
Bing-Zhen Shang, Department of Clinical Trial Ward, Clinical Trial and Conversion Center, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Ling-Chao Liu, Wei-Zhen Zhang, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
En-Ting Lu, Hua-Yang Li, Ming-Ming Xia, Yi Zhang, Department of Gynecology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Co-first authors: Qian-Qian Zhang and Xiao-Qing Lu.
Co-corresponding authors: Jing-Yan Han and Yin Li.
Author contributions: Zhang QQ, Lu XQ, Liu LC, Lu ET, Li HY, Xia MM, and Jin YX collected the data, Zhang QQ and Lu XQ contributed equally to this article and are co-first authors of this manuscript; Zhang QQ, Lu XQ, Shang BZ, Lu ET, Li HY, and Xia MM prepared the original draft; Shang BZ, Zhang Y, and Li Y reviewed and edited the manuscript; Zhang WZ, Zhang Y, Han JY, and Li Y supervised the project; Zhang Y and Li Y contributed to funding acquisition; Han JY and Li Y contributed equally to this article and are co-corresponding authors of this manuscript; all authors thoroughly reviewed and approve the final manuscript.
Supported by the National Key Research and Development Program of China, No. 2020YFA0803801; the National Natural Science Foundation of China, No. 81873568; and the Key Research and Liao Ning Revitalization Talents Program, No. XLYC2412037.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Animal Research Ethics Committee of Peking University, approval No. LA2018061.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Corresponding author: Yin Li, MD, PhD, Associate Professor, Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China. yinli@bjmu.edu.cn
Received: January 8, 2026
Revised: February 2, 2026
Accepted: February 26, 2026
Published online: July 7, 2026
Processing time: 174 Days and 10.8 Hours
Revised: February 2, 2026
Accepted: February 26, 2026
Published online: July 7, 2026
Processing time: 174 Days and 10.8 Hours
Core Tip
Core Tip: This study reveals that the calcium-binding protein S100A11 promotes hepatic and adipose lipid accumulation by upregulating fibroblast growth factor 21, identifying S100A11 as a novel potential therapeutic target for obesity-related metabolic disorders.