Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 28, 2026; 32(24): 119127
Published online Jun 28, 2026. doi: 10.3748/wjg.v32.i24.119127
Published online Jun 28, 2026. doi: 10.3748/wjg.v32.i24.119127
Early screening and risk factors for gastric cancer
Jiao-Jiao Jiang, Ke Chen, Tao Weng, Jie-Min Hong, Wen-Yan Qin, Department of Gastroen
Co-corresponding authors: Jie-Min Hong and Wen-Yan Qin.
Author contributions: Jiang JJ, Hong JM, and Qin WY designed the overall concept and outline of the manuscript; Jiang JJ and Qin WY contributed to the discussion and design of the manuscript; Jiang JJ, Chen K, Wen T, Hong JM, and Qin WY contributed to the writing and editing the manuscript, and review of literature; Hong JM and Qin WY contributed equally as co-corresponding authors. All authors reviewed and approved the final version.
Supported by “Innovation Yongjiang 2035” Key Research and Development Programme, No. 2025Z147.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Wen-Yan Qin, Department of Gastroenterology, Ningbo Hospital of Integrated Traditional Chinese and Western Medicine, No. 998 North Qianhe Road, Yinzhou District, Ningbo 315000, Zhejiang Province, China. tinaqinwenyan@126.com
Received: January 21, 2026
Revised: February 5, 2026
Accepted: March 10, 2026
Published online: June 28, 2026
Processing time: 140 Days and 6.5 Hours
Revised: February 5, 2026
Accepted: March 10, 2026
Published online: June 28, 2026
Processing time: 140 Days and 6.5 Hours
Core Tip
Core Tip: This paper provides a systematic review of risk factors and screening methods for gastric cancer (GC). The review demonstrates that GC development results from the synergistic effects of multiple factors, with Helicobacter pylori infection being the most clearly established class I carcinogen. Gastroscopy remains the gold standard for GC screening. With the future advancement of liquid biopsy and endoscopic techniques, it is anticipated that the early detection rate of GC will significantly improve, mortality rates will decrease, patient prognosis will be enhanced, and the global burden of GC will be alleviated.