Wei ML, Tan QL. Chronic ulcer diagnosis and perforation risk with oral agent contrast-enhanced ultrasound: A case report and review of literature. World J Gastroenterol 2026; 32(24): 119006 [DOI: 10.3748/wjg.v32.i24.119006]
Corresponding Author of This Article
Man-Li Wei, Associate Chief Physician, Department of Ultrasound Medicine, The First People’s Hospital of Nanning, The Fifth Affiliated Hospital of Guangxi Medical University, No. 89 Qixing Road, Qingxiu District, Nanning 530021, Guangxi Zhuang Autonomous Region, China. 260077529@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
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case-report
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Wei ML, Tan QL. Chronic ulcer diagnosis and perforation risk with oral agent contrast-enhanced ultrasound: A case report and review of literature. World J Gastroenterol 2026; 32(24): 119006 [DOI: 10.3748/wjg.v32.i24.119006]
World J Gastroenterol. Jun 28, 2026; 32(24): 119006 Published online Jun 28, 2026. doi: 10.3748/wjg.v32.i24.119006
Chronic ulcer diagnosis and perforation risk with oral agent contrast-enhanced ultrasound: A case report and review of literature
Man-Li Wei, Qing-Lan Tan
Man-Li Wei, Qing-Lan Tan, Department of Ultrasound Medicine, The First People’s Hospital of Nanning, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Wei ML collected clinical information and drafted the initial manuscript; Tan QL critically revised the manuscript for key content; both authors have read and approved the final version to be published.
Supported by Youth Fund for Self-Financed Scientific Research Projects of the Guangxi Zhuang Autonomous Region Health Commission, No. Z20190921.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Man-Li Wei, Associate Chief Physician, Department of Ultrasound Medicine, The First People’s Hospital of Nanning, The Fifth Affiliated Hospital of Guangxi Medical University, No. 89 Qixing Road, Qingxiu District, Nanning 530021, Guangxi Zhuang Autonomous Region, China. 260077529@qq.com
Received: January 29, 2026 Revised: February 27, 2026 Accepted: March 18, 2026 Published online: June 28, 2026 Processing time: 132 Days and 8.1 Hours
Core Tip
Core Tip: Gastric perforation is a rare yet severe complication of abdominal radiotherapy, occurring more frequently when combined immunotherapy and tyrosine kinase inhibitor therapy are administered. Most patients require emergency surgical intervention. This study reports a case where, within the complex context of comprehensive hepatocellular carcinoma treatment (involving radiotherapy, chemotherapy, immunotherapy, and targeted therapy), traditional methods (gastroscopy, contrast-enhanced computed tomography) could not accurately assess ulcer infiltration depth due to blood crust coverage and gastric wall edema. Oral agent contrast-enhanced ultrasound as a novel monitoring tool, clearly demonstrated that the ulcer had reached the serosal layer, thereby successfully predicting impending perforation.
