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World J Gastroenterol. Jun 28, 2026; 32(24): 118709
Published online Jun 28, 2026. doi: 10.3748/wjg.v32.i24.118709
Published online Jun 28, 2026. doi: 10.3748/wjg.v32.i24.118709
Acute liver injury after transcatheter arterial chemoembolization in patients with hepatitis B virus-related intermediate or advanced hepatocellular carcinoma stages
Xin-Hui Jie, Shuang-Shuang Zhang, Graduate School, Xuzhou Medical University, Xuzhou 221006, Jiangsu Province, China
De-Yang Xi, Department of Critical Care Medicine, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province, China
Xue-Bing Yan, Department of Infectious Diseases, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221132, Jiangsu Province, China
Co-first authors: Xin-Hui Jie and De-Yang Xi.
Author contributions: Jie XH and Xi DY share co-first authorship based on their equivalent substantive contributions to experimental execution and analytical rigor throughout this collaborative research; Jie XH contribute to data acquisition, literature screening, literature mining, and manuscript drafting; Xi DY contribute to the study design and statistical analyses; Zhang SS conducted quality assessment; Yan XB provided conceptual guidance and secured funding; all authors have reviewed and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of The Affiliated Hospital of Xuzhou Medical University, No. XYFY2025-KL533-01.
Informed consent statement: Given the retrospective nature of the study without active interventions, the institutional review board waived the requirement for informed consent from patients.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author. Consent was not obtained but the presented data are anonymized and risk of identification is low.
Corresponding author: Xue-Bing Yan, PhD, Professor, Department of Infectious Diseases, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou 221132, Jiangsu Province, China. yxbxuzhou@126.com
Received: January 15, 2026
Revised: February 11, 2026
Accepted: March 10, 2026
Published online: June 28, 2026
Processing time: 144 Days and 14.7 Hours
Revised: February 11, 2026
Accepted: March 10, 2026
Published online: June 28, 2026
Processing time: 144 Days and 14.7 Hours
Core Tip
Core Tip: This study identifies Child-Pugh stage, number of transcatheter arterial chemoembolization (TACE), and hepatitis B virus (HBV) DNA load as independent risk factors for acute liver injury following TACE in patients with HBV-related intermediate to advanced hepatocellular carcinoma. We constructed a practical nomogram that integrates these variables, providing a validated tool for individualized preoperative risk stratification to optimize perioperative management and treatment planning for this specific population.