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World J Gastroenterol. Jun 28, 2026; 32(24): 118637
Published online Jun 28, 2026. doi: 10.3748/wjg.v32.i24.118637
Published online Jun 28, 2026. doi: 10.3748/wjg.v32.i24.118637
Beyond fecal-oral routes - Candida as a reservoir for vertical transmission of Helicobacter pylori: Insights from a murine model
Zeinab Nabil Ahmed Said, Sabah Mohamed Alkhawagah, Department of Medical Microbiology and Immunology, Faculty of Medicine (for Girls), Al-Azhar University, Cairo 11754, Egypt
Author contributions: Said ZNA and Alkhawagah SM contributed equally to this work. Both authors read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Zeinab Nabil Ahmed Said, Department of Medical Microbiology and Immunology, Faculty of Medicine (for Girls), Al-Azhar University, Nasr City, Cairo 11754, Egypt. zeinabnabil@azhar.edu.eg
Received: January 8, 2026
Revised: February 2, 2026
Accepted: March 3, 2026
Published online: June 28, 2026
Processing time: 151 Days and 21.8 Hours
Revised: February 2, 2026
Accepted: March 3, 2026
Published online: June 28, 2026
Processing time: 151 Days and 21.8 Hours
Core Tip
Core Tip: This editorial comments on the article published in the World Journal of Gastroenterology by Xu et al. Helicobacter pylori (H. pylori) represents a significant global pathogen with poorly understood transmission dynamics. The editorial highlights the novel hypothesis of Candida-mediated vertical transmission of H. pylori in a murine model. This model challenges traditional H. pylori transmission routes, urging clinical validation in human cohorts. A comprehensive understanding of the transmission routes of H. pylori will help pave the way for implementing effective infection prevention and control measures.