Clinical features and biomarker research advances in immunoglobulin 4-related digestive system disorders

doi:10.3748/wjg.v32.i23.118782

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jun 21, 2026; 32(23): 118782
Published online Jun 21, 2026. doi: 10.3748/wjg.v32.i23.118782

Clinical features and biomarker research advances in immunoglobulin 4-related digestive system disorders

Yue Pan, Yu-Zhang Jiang

Yue Pan, Yu-Zhang Jiang, Department of Laboratory Medicine, The Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University, Huai’an 223300, Jiangsu Province, China

Author contributions: Pan Y was responsible for the literature review, data collection, and drafting the manuscript; Jiang YZ was responsible for conceptualization, review, and editing. All authors have read and approved the final manuscript.

AI contribution statement: During the preparation of this work, the authors used ChatGPT in order to improve language. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.

Supported by Open Research Project of the Huai’an ‘Tian Yixing’ Key Laboratory of Medical Laboratory Science, No. HAP202004.

Conflict-of-interest statement: The authors declare no conflict of interest.

Corresponding author: Yu-Zhang Jiang, Professor, Department of Laboratory Medicine, The Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University, No. 1 West Huanghe Road, Huai’an 223300, Jiangsu Province, China. jyz8848@163.com

Received: January 12, 2026
Revised: January 31, 2026
Accepted: March 16, 2026
Published online: June 21, 2026
Processing time: 148 Days and 21.2 Hours

Core Tip

Core Tip: Given that immunoglobulin-related digestive system disorders frequently mimic malignancies, leading to misdiagnosis, this review systematically maps the clinical spectrum from classical (pancreato-biliary) to rare (esophageal/mesenteric) manifestations. A key highlight is the paradigm shift from single-marker diagnosis to multidimensional biomarker assessment (e.g., plasma blasts, interferon-α-interleukin-33 axis). It focuses on the utility of these novel markers in monitoring disease activity and predicting fibrosis, providing evidence-based strategies for early recognition and personalized management.