Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 21, 2026; 32(23): 118199
Published online Jun 21, 2026. doi: 10.3748/wjg.v32.i23.118199
Published online Jun 21, 2026. doi: 10.3748/wjg.v32.i23.118199
Gallbladder cancer: Is significant attention to this pathology justified?
Vladislav V Tsukanov, Alexander V Vasyutin, Edward V Kasparov, Julia L Tonkikh, Clinical Department of the Digestive System Pathology of Adults and Children, Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, Krasnoyarsk 660022, Russia
Author contributions: Tsukanov VV designed the overall concept and outline of the manuscript; Tsukanov VV, Vasyutin AV and Kasparov EV participated in drafting the manuscript; Tsukanov VV and Kasparov EV reviewed and edited the manuscript; Vasyutin AV wrote the original draft; Tonkikh JL reviewed the literature; Tsukanov VV, Vasyutin AV, Kasparov EV and Tonkikh JL contributed to this paper; all authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Corresponding author: Vladislav V Tsukanov, MD, PhD, Full Professor, Clinical Department of the Digestive System Pathology of Adults and Children, Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, 3-G Partizan Zheleznyak Street, Krasnoyarsk 660022, Russia. gastro@impn.ru
Received: December 28, 2025
Revised: January 28, 2026
Accepted: March 10, 2026
Published online: June 21, 2026
Processing time: 164 Days and 3.1 Hours
Revised: January 28, 2026
Accepted: March 10, 2026
Published online: June 21, 2026
Processing time: 164 Days and 3.1 Hours
Core Tip
Core Tip: Gallbladder cancer is characterized by high malignancy, a 5-year survival rate of less than 10%, and is extremely difficult to early diagnosis. Modern epidemiological studies highlight a strong association of gallbladder cancer with cholelithiasis, gastric cancer, hepatocellular carcinoma, pancreatic cancer and colorectal cancer. Investigation of the mechanisms of interaction between bile acids, gastrointestinal microbiota, the immune response, and metabolic pathways may be the primary pathogenetic paradigm for explaining this phenomenon and offers clear prospects for the development of new research directions to improve therapeutic and preventive technologies.