Ren YT, Wen JY, Tu JJ, Zhang H, Ding CF, Xiao JQ, Zhuge YZ. Development and validation of a nomogram predicting rebleeding in cirrhotic patients with patent transjugular intrahepatic portosystemic shunt. World J Gastroenterol 2026; 32(23): 118142 [DOI: 10.3748/wjg.v32.i23.118142]
Corresponding Author of This Article
Yu-Zheng Zhuge, PhD, Professor, Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing 210000, Jiangsu Province, China. yuzheng9111963@aliyun.com
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
research-article
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Ren YT, Wen JY, Tu JJ, Zhang H, Ding CF, Xiao JQ, Zhuge YZ. Development and validation of a nomogram predicting rebleeding in cirrhotic patients with patent transjugular intrahepatic portosystemic shunt. World J Gastroenterol 2026; 32(23): 118142 [DOI: 10.3748/wjg.v32.i23.118142]
Yang-Tian Ren, Jun-Yi Wen, Jing-Jing Tu, Han Zhang, Chuan-Fu Ding, Jiang-Qiang Xiao, Yu-Zheng Zhuge, Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210000, Jiangsu Province, China
Co-corresponding authors: Jing-Jing Tu and Yu-Zheng Zhuge.
Author contributions: Ren YT and Zhang H participated in the conception and design of the study and were involved in the acquisition, analysis, or interpretation of the data; Ren YT wrote the manuscript; Wen JY, Tu JJ, and Ding CF accessed and verified the study data; Tu JJ and Zhuge YZ are designated as co-corresponding authors because they contributed equally to overseeing the research project, guiding the clinical data analysis, and finalizing the manuscript; Ren YT, Wen JY, Tu JJ, Zhang H, Ding CF, Xiao JQ, Zhuge YZ critically reviewed and provided final approval of the manuscript; all authors were responsible for the decision to submit the manuscript for publication.
Supported by the National Natural Science Foundation of China, No. 82100652; and the Nanjing Drum Hospital Youth Development Program, No. 2024-LCYJ-PY-27.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Nanjing Drum Tower Hospital (approval No. 2024-410-02).
Informed consent statement: All study participants provided verbal informed consent before study enrolment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: No additional data are available.
Corresponding author: Yu-Zheng Zhuge, PhD, Professor, Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing 210000, Jiangsu Province, China. yuzheng9111963@aliyun.com
Received: December 25, 2025 Revised: February 28, 2026 Accepted: March 12, 2026 Published online: June 21, 2026 Processing time: 165 Days and 21.3 Hours
Core Tip
Core Tip: Rebleeding following technically patent transjugular intrahepatic portosystemic shunt (TIPS) placement remains a significant clinical challenge, especially with the use of reduced-diameter stents aimed at mitigating overt hepatic encephalopathy. Although smaller stents decrease procedure-related complications, they may increase the risk of insufficient shunt flow and subsequent variceal rebleeding. This study identified patients experiencing rebleeding despite shunt patency and evaluated pre-procedural factors associated with this adverse outcome. By establishing a predictive nomogram, this research provides a practical tool for screening high-risk individuals, ultimately supporting individualized clinical decision-making and the selection of optimal TIPS diameters for cirrhotic patients.
