Ning HB, Jin HM, Peng Z, Li K, Shang J. Bone and renal safety of initial antiviral therapy using tenofovir alafenamide fumarate or entecavir for chronic hepatitis B. World J Gastroenterol 2026; 32(22): 117500 [DOI: 10.3748/wjg.v32.i22.117500]
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Ning HB, Jin HM, Peng Z, Li K, Shang J. Bone and renal safety of initial antiviral therapy using tenofovir alafenamide fumarate or entecavir for chronic hepatitis B. World J Gastroenterol 2026; 32(22): 117500 [DOI: 10.3748/wjg.v32.i22.117500]
Hui-Bin Ning, Hui-Ming Jin, Zhen Peng, Kuan Li, Jia Shang, Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou 450000, Henan Province, China
Author contributions: Ning HB designed the research and wrote the first manuscript; Ning HB, Jin HM, Peng Z and Li K contributed to conceiving the research and analyzing data; Ning HB and Shang J conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Henan Provincial People's Hospital, No. 21, 2019.
Informed consent statement: All the study subjects provided informed consent.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data are available.
Received: January 6, 2026 Revised: January 29, 2026 Accepted: March 17, 2026 Published online: June 14, 2026 Processing time: 142 Days and 19.5 Hours
Core Tip
Core Tip: Nucleoside/nucleotide analogs are currently the core drugs for the antiviral treatment of chronic hepatitis B (CHB). Among them, entecavir (ETV) and tenofovir alafenamide fumarate (TAF) are recommended as first-line treatment regimens in domestic and international guidelines due to their potent antiviral activity and low resistance rates. However, direct comparative data between TAF and ETV remain limited, particularly in long-term follow-up studies of Chinese CHB populations. The long-term differences in bone and renal safety between TAF and ETV warrant further investigation. Therefore, this study aims to provide critical insights for optimizing individualized treatment strategies for CHB by comparing the clinical efficacy and safety profiles of ETV and TAF.
