Telomere and telomerase: Traditional tumor targets regain their applications for liver cancer diagnosis and prognosis

doi:10.3748/wjg.v32.i21.116363

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jun 7, 2026; 32(21): 116363
Published online Jun 7, 2026. doi: 10.3748/wjg.v32.i21.116363

Telomere and telomerase: Traditional tumor targets regain their applications for liver cancer diagnosis and prognosis

Xin-Ya Lu, Yi-Gang Wang, Hui Wang

Xin-Ya Lu, Yi-Gang Wang, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China

Hui Wang, Department of Oncology, Zhejiang Xiaoshan Hospital, Hangzhou 311200, Zhejiang Province, China

Author contributions: Lu XY, Wang YG and Wang H contributed to this paper; Wang YG and Wang H designed the outline of the manuscript; Lu XY and Wang H contributed to the writing, editing the manuscript and review of literature.

AI contribution statement: DeepSeek was merely used for English translation and linguistic polishing on the basis of author-summarized content.

Supported by the Hangzhou Medical Health Science and Technology Project, No. B20220173; and Joint Fund of Zhejiang Provincial Natural Science Foundation of China, No. LKLY25H160002.

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

Corresponding author: Hui Wang, MD, Doctor, Department of Oncology, Zhejiang Xiaoshan Hospital, No. 728 Yucai North Road, Xiaoshan District, Hangzhou 311200, Zhejiang Province, China. wanghui19840106@126.com

Received: November 10, 2025
Revised: December 18, 2025
Accepted: January 21, 2026
Published online: June 7, 2026
Processing time: 197 Days and 15.2 Hours

Core Tip

Core Tip: This editorial emphasizes the pivotal role of telomere biology in hepatocellular carcinoma, spanning fundamental molecular mechanisms and their clinical implications. It outlines the diagnostic and prognostic value of non-invasive liquid biopsy approaches based on telomere length assessment and TERT mutation analysis. Furthermore, the editorial discusses emerging therapeutic strategies, particularly telomerase-targeted immunotherapies, underscoring their potential to advance precision oncology in hepatocellular carcinoma and other malignancies.