Salidroside mitigates experimental colitis through cyclic adenosine monophosphate pathway activation and suppression of enteric glial cell responses
Yan Li, Sha-Sha Tao, Yan Wang, Qian Sun, Meng-Ying Li, Hua Zhang, Yun-Qing Li
Yan Li, Yun-Qing Li, College of Life Sciences, Northwest University, Xi’an 710069, Shaanxi Province, China
Yan Li, Sha-Sha Tao, Yan Wang, Yun-Qing Li, Department of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Qian Sun, Hua Zhang, Yun-Qing Li, Department of Geriatrics, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China
Meng-Ying Li, Department of Endocrinology, Xijing Hospital, The Fourth Medical University, Xi’an 710032, Shaanxi Province, China
Co-corresponding authors: Hua Zhang and Yun-Qing Li.
Author contributions: Li Y conceived the study, performed animal experiments, acquired data, and drafted the manuscript; Tao SS and Wang Y established the dextran sulfate sodium salt colitis model, conducted histological scoring and immunofluorescence; Sun Q and Zhang H carried out Western blot analyses; Li MY contributed to providing network pharmacology predictions supported by whole-transcriptome profiling; Li YQ supervised the project, guided the experiments, and critically revised the manuscript.
AI contribution statement: No AI tools were used during any stage of this study, including manuscript writing, data processing, figure, and interpretation of results. All content is the original work of the authors.
Supported by the National Natural Science Foundation of China, No. 82504388, No. 82471254 and No. 82221001; and the Key Research and Development Program of Shaanxi Province, No. 2022SF160.
Institutional review board statement: This study did not involve human participants or human-derived materials.
Institutional animal care and use committee statement: All animal experiments were reviewed and approved by the Institutional Animal Care and Use Committee of The Fourth Military Medical University, in accordance with the Guide for the Care and Use of Laboratory Animals. The approved protocol number was No. IACUC-20220420.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Corresponding author: Yun-Qing Li, PhD, Professor, College of Life Sciences, Northwest University, No. 229 Taibai North Road, Beilin District, Xi’an 710069, Shaanxi Province, China.
deptanat@fmmu.edu.cn
Received: November 17, 2025
Revised: January 13, 2026
Accepted: March 6, 2026
Published online: June 7, 2026
Processing time: 190 Days and 14.9 Hours
