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World J Gastroenterol. May 28, 2026; 32(20): 116036
Published online May 28, 2026. doi: 10.3748/wjg.v32.i20.116036
Published online May 28, 2026. doi: 10.3748/wjg.v32.i20.116036
Therapeutic effects of rhubarb enema on Th17 cell and systemic inflammatory response in clinical acute pancreatitis
Lin-Gui Zhong, Chuan-Jiang Wang, Department of Emergency Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China
Yu Luo, Department of Outpatient, Chongqing Mental Health Center, Chongqing 400000, China
Fang Gao, Department of Science and Education, Chongqing Mental Health Center, Chongqing 400000, China
Ting-Ting Guo, Department of General Medicine, Community Health Service Center, Long
Jian Yang, Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China
Jian Yang, Department of Gastroenterology, Changdu People’s Hospital of Xizang, Changdu 854000, Tibet Autonomous Region, China
Co-first authors: Lin-Gui Zhong and Yu Luo.
Co-corresponding authors: Jian Yang and Chuan-Jiang Wang.
Author contributions: Zhong LG and Luo Y contribute equally to this study as co-first authors; Yang J and Wang CJ contribute equally to this study as co-corresponding authors; Wang CJ and Yang J performed conception hypothesis and design; Zhong LG and Luo Y performed data acquisition and analysis; Wang CJ and Gao F performed manuscript preparation; Yang J revised manuscript; Guo TT searched and collected bibliography.
Supported by Chongqing Science and Technology Foundation, No. CSTB2025NSCQ-GPX1217; 2024 Nursing Research Innovation Project of the First Affiliated Hospital of Chongqing Medical University, No. HLPY2024-10; Natural Science Foundation of Tibet Autonomous Region, No. XZ2024ZR-ZY100(Z); Program for Youth Innovation in Future Medicine, Chongqing Medical University, No. W0138; and Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in the Three Gorges Reservoir Area Project, No. KFKT2022009.
Institutional review board statement: The protocol was approved by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University (Approval No. 2022-077).
Clinical trial registration statement: This trial has been prospectively registered on a publicly accessible clinical trial registry (Chinese Clinical Trial Registry) with the registration identifier (ChiCTR2100046548).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: There is no conflict of interest.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Corresponding author: Chuan-Jiang Wang, PhD, Department of Emergency Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Chongqing 400000, China. wangchuanjiang@cqmu.edu.cn
Received: December 26, 2025
Revised: February 5, 2026
Accepted: March 4, 2026
Published online: May 28, 2026
Processing time: 145 Days and 0.1 Hours
Revised: February 5, 2026
Accepted: March 4, 2026
Published online: May 28, 2026
Processing time: 145 Days and 0.1 Hours
Core Tip
Core Tip: Acute pancreatitis (AP) is a disease with high mortality, caused by the activation of pancreatic enzymes due to multiple factors and characterized by localized pancreatic inflammation. Pharmacological studies indicate that rhubarb significantly improves intestinal blood perfusion, suppresses excessive inflammatory responses, modulates inflammatory mediator cascades, and enhances intestinal motility. However, whether rhubarb improves the prognosis and complications in patients with AP by inhibiting Th17 cell differentiation and inflammatory responses remains unclear. Therefore, this study was conducted to evaluate the role of rhubarb in patients with AP.