Hao Jiang, Jin-Hua Yan, Wen-Jing Tang, Bin Shen, Shuai Mo, Yang Wang, De-Hua Hu, Zhi-Xiong Dong, Shu-Bing Zhang
Hao Jiang, Bin Shen, Shuai Mo, De-Hua Hu, Department of Biomedical Informatics, School of Life Sciences, Central South University, Changsha 410013, Hunan Province, China
Jin-Hua Yan, Wen-Jing Tang, Yang Wang, Shu-Bing Zhang, Department of Cell Biology, School of Life Sciences, Central South University, Changsha 410013, Hunan Province, China
Zhi-Xiong Dong, Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325053, Zhejiang Province, China
Co-first authors: Hao Jiang and Jin-Hua Yan.
Co-corresponding authors: Zhi-Xiong Dong and Shu-Bing Zhang.
Author contributions: Jiang H, Dong ZX and Zhang SB designed the research study; Dong ZX, Zhang SB helped to supervised the study; Jiang H, Yan JH and Tang WJ performed most experiments, analyzed the data, wrote the manuscript and edited the paper; Wang Y, Shen B and Mo S contributed to new reagents and analytic tools; Hu DH helped to perform the experiments and analyzed the data; Jiang H and Zhang SB helped to edit the paper; all authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82573818; the Natural Science Foundation of Hunan Province of China, No. 2025JJ50542; and Key Laboratory of School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, No. JS2023005.
Institutional review board statement: The study was approved by the Ethics Committee of School of Life Sciences, Central South University (approval No. 2021-1-46).
Institutional animal care and use committee statement: All animal experiments were approved by the Ethics Committee of School of Life Sciences, Central South University (approval No. 2021-2-56).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All the data generated or analyzed in this study are included in this published article. The data are available upon request from the corresponding author.
Corresponding author: Shu-Bing Zhang, MD, Professor, Department of Cell Biology, School of Life Sciences, Central South University, No. 172 Tongzipo, Yuelu District, Changsha 410013, Hunan Province, China.
shubingzhang@csu.edu.cn
Received: October 17, 2025
Revised: December 28, 2025
Accepted: February 14, 2026
Published online: May 21, 2026
Processing time: 214 Days and 19.4 Hours
