Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2025; 31(8): 102024
Published online Feb 28, 2025. doi: 10.3748/wjg.v31.i8.102024
Role of Helicobacter pylori infection and the risk of cholelithiasis
Nicolò Fabbri, Salvatore Greco, Antonio Pesce, Francesco Virgilio, Danila Romeo, Carlo V Feo
Nicolò Fabbri, Antonio Pesce, Carlo V Feo, Unit of General Surgery, Local Health Agency of Ferrara, Ferrara 44100, Emilia-Romagna, Italy
Salvatore Greco, Unit of Internal Medicine, Local Health Agency of Ferrara, Ferrara 44100, Emilia-Romagna, Italy
Antonio Pesce, Carlo V Feo, Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, Ferrara 44100, Emilia-Romagna, Italy
Francesco Virgilio, Unit of Hepato-Biliary Surgery, IRCCS San Raffaele Hospital, Milan 20132, Lombardy, Italy
Danila Romeo, Local Health Agency of Ferrara, Ferrara 44100, Emilia-Romagna, Italy
Co-first authors: Nicolò Fabbri and Salvatore Greco.
Co-corresponding authors: Nicolò Fabbri and Danila Romeo.
Author contributions: Fabbri N, Greco S, Pesce A, Virgilio F, Romeo D, and Feo CV contributed to this work; Fabbri N and Romeo D equally contributed as co-corresponding authors; Fabbri N and Greco S wrote and edited the manuscript, contributing equally as co-first authors; Feo CV revised the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nicolò Fabbri, MD, Unit of General Surgery, Local Health Agency of Ferrara, 2 Via Valle Oppio, Ferrara 44100, Emilia-Romagna, Italy. n.fabbri@ausl.fe.it
Received: October 5, 2024
Revised: October 29, 2024
Accepted: December 18, 2024
Published online: February 28, 2025
Processing time: 109 Days and 6.5 Hours
Core Tip

Core Tip: This article discusses the role of Helicobacter pylori (H. pylori) in cholelithiasis and bilirubin metabolism, highlighting a study by Yao et al that suggests an association between H. pylori infection and gallstones. While the study provides evidence for this link, it notes that the relationship may vary across populations due to factors like strain differences and geographic prevalence. The article also explores the potential role of proton pump inhibitors in increasing cholelithiasis risk, and emphasizes the need for further research into the gut microbiota’s involvement in gallstone pathogenesis.