Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2025; 31(7): 103400
Published online Feb 21, 2025. doi: 10.3748/wjg.v31.i7.103400
Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma
Yu-Bo Liang, Xing-Ming Chen, Wan-Ling Luo, Yang Ke
Yu-Bo Liang, Xing-Ming Chen, Wan-Ling Luo, Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China
Yang Ke, Department of Hepatobiliary Surgery and Department of Surgical Education and Research, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China
Co-first authors: Yu-Bo Liang and Xing-Ming Chen.
Author contributions: Liang YB, Chen XM, and Luo WL interpretated the data and drafted the manuscript, Liang YB and Chen XM contributed equally as co-first authors; Ke Y designed the letter and reviewed and edited it critically; and all authors approved the final version to be published and agreed to be accountable for all aspects of the manuscript.
Supported by the National Natural Science Foundation of China, No. 82103173 and No. 82460461; Medical Subject Leader of Yunnan Province (General Surgery), No. D-2024029; Yunnan Fundamental Research Project for Excellent Young Scholars, No. 202401AW070003; and the Young and Mid-aged Academic and Technical Leader Reserve Talent Program of Yunnan Province, No. 202205AC160063.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yang Ke, MD, PhD, Department of Hepatobiliary Surgery and Department of Surgical Education and Research, The Second Affiliated Hospital of Kunming Medical University, No. 374 Kunrui Road, Wuhua District, Kunming 650101, Yunnan Province, China. keyang1218@126.com
Received: November 19, 2024
Revised: December 19, 2024
Accepted: December 31, 2024
Published online: February 21, 2025
Processing time: 62 Days and 15.8 Hours
Core Tip

Core Tip: Hepatocellular carcinoma (HCC) is a type of highly aggressive tumor with poor prognosis. Therefore, a deeper understanding of molecular mechanism underlying HCC recurrence is crucial to effective treatment of HCC patients. This letter comments recent findings that the m6A-modified long noncoding RNA kinesin family member 9-antisense RNA 1 promotes stemness and sorafenib resistance of HCC through ubiquitin-specific peptidase 1-mediated deubiquitination of oncogene short stature homeobox 2, and we propose that kinesin family member 9-antisense RNA 1 and oncogene short stature homeobox 2 are potential prognostic markers and therapeutic targets of HCC.