Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia

doi:10.3748/wjg.v31.i7.100051

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Feb 21, 2025; 31(7): 100051
Published online Feb 21, 2025. doi: 10.3748/wjg.v31.i7.100051

Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia

Nikko Darnindro, Murdani Abdullah, Ninik Sukartini, Cleopas M Rumende, Amanda Pitarini, Saskia A Nursyirwan, Achmad Fauzi, Dadang Makmun, Erni J Nelwan, Hamzah Shatri, Ikhwan Rinaldi, Caroline Tanadi

Nikko Darnindro, Murdani Abdullah, Amanda Pitarini, Saskia A Nursyirwan, Achmad Fauzi, Dadang Makmun, Division of Gastroenterology, Pancreatobiliary and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta 10430, Indonesia

Nikko Darnindro, Division of Gastrohepatology, Department of Internal Medicine, Fatmawati General Hospital, Jakarta 12430, Indonesia

Murdani Abdullah, Human Cancer Research Center, IMERI Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia

Ninik Sukartini, Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta 10430, Indonesia

Cleopas M Rumende, Division of Respirology and Critical Care, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta 10430, Indonesia

Erni J Nelwan, Division of Tropical Medicine and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta 10430, Indonesia

Hamzah Shatri, Division of Psychosomatic and Palliative Medicine, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta 10430, Indonesia

Ikhwan Rinaldi, Division of Haematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta 10430, Indonesia

Caroline Tanadi, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta 14440, Indonesia

Author contributions: Darnindro N, Abdullah M, Sukartini N, Nelwan EJ, Shatri H, and Rinaldi I designed and analyzed the data; Rumende CM, Pitarini A, Nursyirwan SA, and Fauzi A conducted the study; Makmun D and Tanadi C contributed to the analysis. All authors have contributed to drafting and revising the article and have approved the final version for submission.

Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Faculty of Medicine, Universitas Indonesia (No. KET-1517/UN2.F1/ETIK/PPM.00.02/2023).

Informed consent statement: Informed consent was obtained from all individual participants.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised accordingly.

Data sharing statement: Any other data not provided in the manuscript are available from the corresponding author at nikkodarnindro@gmail.com.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Nikko Darnindro, MD, Division of Gastroenterology, Pancreatobiliary and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jl. Pangeran Diponegoro No. 71, Kenari, Kec. Senen, Kota Jakarta Pusat, Daerah Khusus Ibukota, Jakarta 10430, Indonesia. nikkodarnindro@gmail.com

Received: August 6, 2024
Revised: December 5, 2024
Accepted: December 23, 2024
Published online: February 21, 2025
Processing time: 167 Days and 2.4 Hours

Core Tip

Core Tip: Previous studies have reported several specific microbiotas with colorectal cancer. However, these studies mainly involved fecal samples instead of colonic mucosal samples and thus could be biased. In addition, studies from Indonesian patients are still very limited and the results may differ from other countries. This study showed that there was a significant difference in the microbiota composition and diversity between patients with colorectal cancer and non-colorectal cancer in Indonesia. These results could potentially be used as a diagnostic and prognostic biomarker for colorectal cancer.