Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2025; 31(6): 96782
Published online Feb 14, 2025. doi: 10.3748/wjg.v31.i6.96782
Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway
Han-Ning Xuan Yuan, Hyun Sung Kim, Gye Ryeol Park, Jae Eun Ryu, Ji Eun Kim, In Young Kang, Hye Young Kim, Seung Min Lee, Ju Hee Oh, Eileen L Yoon, Dae Won Jun
Han-Ning Xuan Yuan, Dae Won Jun, Department of Internal Medicine, Hanyang University School of Medicine, Seoul 04763, South Korea
Hyun Sung Kim, Department of Pathology, Hanyang University School of Medicine, Seoul 04763, South Korea
Gye Ryeol Park, Jae Eun Ryu, Ji Eun Kim, In Young Kang, Hye Young Kim, Seung Min Lee, Department of Translational Medicine, Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, South Korea
Ju Hee Oh, Department of Obstetrics and Gynecology, Institute of Women’s Medical Life Science, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul 04763, South Korea
Eileen L Yoon, Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 01757, South Korea
Co-corresponding authors: Eileen L Yoon and Dae Won Jun.
Author contributions: Yoon EL and Jun DW designed the research study; Kang IY, Ryu JE, Park GR, Oh JH, and Kim JE performed the research; Kang IY analyzed liver organoids; Kim HS analyzed animal model data; Lee SM and Yoon EL contributed to the clarification and explanation of the finding; Xuan Yuan HN wrote the manuscript; All authors have read and approved the final manuscript.
Supported by the National Research Foundation of Korea Grant Funded by the Korea Government, No. RS-2024-00440477; and the Korea Institute of Science and Technology Institutional Program, No. 2E33111-24-042.
Institutional review board statement: The study does not involve human subjects, and therefore, it does not require institutional review board approval.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Hanyang University, No. HY-IACUC-2022-0217A and No. HY-IACUC-2023-0276A.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The data supporting the findings of this study can be requested directly from the corresponding author, at the email address (noshin@hanyang.ac.kr).
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dae Won Jun, PhD, Chief Doctor, Department of Internal Medicine, Hanyang University School of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. noshin@hanyang.ac.kr
Received: May 15, 2024
Revised: October 25, 2024
Accepted: December 11, 2024
Published online: February 14, 2025
Processing time: 240 Days and 1.7 Hours
Core Tip

Core Tip: Targeting the adenosine triphosphate-binding pocket of mixed lineage kinase domain-like protein may provide a novel therapeutic strategy for reducing inflammation in alcoholic liver disease, independent of its role in necroptosis, highlighting its potential as a unique target in liver disease management.