Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2025; 31(5): 98732
Published online Feb 7, 2025. doi: 10.3748/wjg.v31.i5.98732
Hollow cerium nanoparticles synthesized by one-step method for multienzyme activity to reduce colitis in mice
Lin Mi, Kai Zhang, Jian-Xia Ma, Jian-Feng Yao, Yi-Li Tong, Zhi-Jun Bao
Lin Mi, Kai Zhang, Yi-Li Tong, Department of General Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China
Jian-Xia Ma, Jian-Feng Yao, Zhi-Jun Bao, Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai 200040, China
Author contributions: Mi L designed the research and wrote the paper; Mi L, Zhang K, and Tong YL performed the majority of the experiments; Mi L, Ma JX, Yao JF, and Bao ZJ analysed the data.
Institutional animal care and use committee statement: This study has received ethical approval for animal experiments, No. 2022JS Huadong Hospital-081.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All relevant data are within the manuscript and its additional files.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Jun Bao, MD, Professor, Department of Gastroenterology, Huadong Hospital, Fudan University, No. 221 West Yan’an Road, Shanghai 200040, China. zhijunbao@fudan.edu.cn
Received: July 4, 2024
Revised: October 8, 2024
Accepted: December 4, 2024
Published online: February 7, 2025
Processing time: 179 Days and 5.4 Hours
Core Tip

Core Tip: Inflammatory bowel disease (IBD) is a common chronic intestinal inflammatory disease. High oxidative stress is a treatment target for IBD. Cerium oxide nanomaterials as nanozymes with antioxidant activity are potential drugs for the treatment of colitis. To synthesize hollow cerium (H-CeO2) nanoparticles by one-step method and to study the physicochemical properties, biosafety, and therapeutic efficacy of H-CeO2 in IBD. In this study, we found that a one-step synthesis of H-CeO2 nanomaterials has good antioxidant activity, biosafety, and can inhibit the development of dextran sulphate sodium-induced IBD in mice by scavenging reactive oxygen species.