Xu CY, Zheng ZH, Yang K, Wu RR, Cao JQ, Duan JY. Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis. World J Gastroenterol 2025; 31(43): 112483 [DOI: 10.3748/wjg.v31.i43.112483]
Corresponding Author of This Article
Jin-Yuan Duan, PhD, Associate Chief Physician, Department of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1519 Dongyue Avenue, Nanchang 330000, Jiangxi Province, China. duanjy2022@outlook.com
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Gastroenterology & Hepatology
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Basic Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 21, 2025 (publication date) through Nov 20, 2025
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World Journal of Gastroenterology
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1007-9327
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Xu CY, Zheng ZH, Yang K, Wu RR, Cao JQ, Duan JY. Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis. World J Gastroenterol 2025; 31(43): 112483 [DOI: 10.3748/wjg.v31.i43.112483]
World J Gastroenterol. Nov 21, 2025; 31(43): 112483 Published online Nov 21, 2025. doi: 10.3748/wjg.v31.i43.112483
Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis
Chi-Ying Xu, Kun Yang, Ren-Ran Wu, Jin-Yuan Duan, Department of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, Jiangxi Province, China
Zhi-Hua Zheng, Jia-Qing Cao, Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330000, Jiangxi Province, China
Co-first authors: Chi-Ying Xu and Zhi-Hua Zheng.
Author contributions: Xu CY and Zheng ZH are co-first authors who have made significant contributions to this article; Xu CY, Zheng ZH, Cao JQ and Duan JY contributed to the conception of the study; Xu CY, Zheng ZH, Yang K and Wu RR performed the experiment; Cao JQ and Duan JY helped perform the analysis with constructive discussions; Xu CY, Zheng ZH, Cao JQ and Duan JY performed the data analyses and wrote the manuscript; all correspondence should be directed to Duan JY. All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82360168 and No. 81960154; Natural Science Foundation of Jiangxi Province, No. 20212BAB206020; and the Foundation of Health Commission of Jiangxi Province, No. 202310024.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Affiliated Hospital of Nanchang University.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at duanjy2022@outlook.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Yuan Duan, PhD, Associate Chief Physician, Department of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1519 Dongyue Avenue, Nanchang 330000, Jiangxi Province, China. duanjy2022@outlook.com
Received: July 29, 2025 Revised: September 2, 2025 Accepted: October 13, 2025 Published online: November 21, 2025 Processing time: 115 Days and 1.1 Hours
Core Tip
Core Tip: Distal small bowel resection with preservation of the terminal ileum (DBRPI) improves glucose tolerance and reduces weight in high-fat diet-fed rats. This effect is linked to altered gut microbiota and bile acids: Increased Prevotellaceae_NK3B31_group and 7-ketolithocholic acid (7-KLCA), alongside decreased Desulfovibrio fairfieldensis and α-muricholic acid. DBRPI upregulates ileal farnesoid X receptor (FXR) and glucagon-like peptide-1 (GLP-1) expression, and downregulates hepatic gluconeogenic genes. Critically, Prevotellaceae_NK3B31_group correlates positively with 7-KLCA and FXR, and negatively with glucose intolerance and gluconeogenesis. Thus, DBRPI likely improves glucose metabolism by activating the Prevotellaceae-mediated 7-KLCA-FXR pathway, enhancing GLP-1, and suppressing hepatic glucose production.
