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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2025; 31(43): 111358
Published online Nov 21, 2025. doi: 10.3748/wjg.v31.i43.111358
Published online Nov 21, 2025. doi: 10.3748/wjg.v31.i43.111358
Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach
Wei-Wei Dong, Tao Liu, Wen-Ting He, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu Province, China
Wei-Wei Dong, Tao Liu, Wen-Ting He, Gansu Provincial Key Laboratory of Environmental Oncology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China
Wei-Wei Dong, Tao Liu, Wen-Ting He, Digestive System Tumor Prevention and Treatment and Translational Medicine Engineering Innovation Center of Lanzhou University, Lanzhou University, Lanzhou 730000, Gansu Province, China
Li-Xia He, Division of Molecular and Cellular Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, United States
Co-corresponding authors: Li-Xia He and Wen-Ting He.
Author contributions: He WT and He LX conceived the topic; Dong WW wrote the original manuscript; He WT, He LX and Liu T revised the review; all authors have read and agreed to the published version of the manuscript.
Supported by the Science and Technology Program of Gansu Province, No. 23JRRA1015.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Ting He, PhD, Doctor, The Second Hospital and Clinical Medical School, Lanzhou University, No. 82 Cuiyingmen, Chengguan District, Lanzhou 730030, Gansu Province, China. hewt@lzu.edu.cn
Received: June 30, 2025
Revised: September 14, 2025
Accepted: October 21, 2025
Published online: November 21, 2025
Processing time: 144 Days and 22.9 Hours
Revised: September 14, 2025
Accepted: October 21, 2025
Published online: November 21, 2025
Processing time: 144 Days and 22.9 Hours
Core Tip
Core Tip: This review examines pyroptosis as a pivotal mechanism in inflammatory bowel disease (IBD) pathogenesis, driving inflammation and tissue damage. It evaluates therapeutic strategies targeting pyroptosis pathways, emphasizing their potential to modulate disease progression. Key challenges including drug specificity, delivery, and safety are analyzed, alongside opportunities for combination therapies. The discussion highlights the need for precision approaches and improved translational models to advance pyroptosis-targeted treatments for IBD. Future directions focus on overcoming current limitations to optimize clinical outcomes.