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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2025; 31(41): 112794
Published online Nov 7, 2025. doi: 10.3748/wjg.v31.i41.112794
Published online Nov 7, 2025. doi: 10.3748/wjg.v31.i41.112794
Uncommon causes of acute small intestinal bleeding-invasive mole: A case report and review of literature
Wei-Hua Yu, Jiang-Wei Zhou, Department of Gastroenterology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Yiwu 322000, Zhejiang Province, China
Yi Zong, Department of Radiology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Yiwu 322000, Zhejiang Province, China
Guo-Qiang Xu, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang Uni
Author contributions: Yu WH contributed to the manuscript writing and editing; Zong Y and Zhou JW contributed to the data collection; Yu WH, Zong Y, and Zhou JW contributed to data analysis, Xu GQ contributed to the conceptualization and supervision; and all authors read and approved the final manuscript.
Informed consent statement: An informed written consent was obtained from the patient for the publication of this report, and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Qiang Xu, MD, Professor, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. 1193065@zju.edu.cn
Received: August 7, 2025
Revised: September 7, 2025
Accepted: September 28, 2025
Published online: November 7, 2025
Processing time: 92 Days and 4.3 Hours
Revised: September 7, 2025
Accepted: September 28, 2025
Published online: November 7, 2025
Processing time: 92 Days and 4.3 Hours
Core Tip
Core Tip: Gastrointestinal bleeding due to small intestinal tumors, especially metastatic tumors, is rare. We describe a rare case of metastatic invasive mole that caused acute small intestinal bleeding. The capsule endoscopy and enteroscopy detected jejunal lesions with features of trophoblastic tumor on biopsy. The patient underwent resection of the involved jejunal segment. The histopathology of the resected specimen confirmed the diagnosis of invasive mole. For women of childbearing age, who present with gastrointestinal bleeding and elevated human chorionic gonadotropin, after pregnancy is ruled out, metastatic trophoblastic tumor must be included in the differential diagnoses.