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World J Gastroenterol. Oct 7, 2025; 31(37): 112388
Published online Oct 7, 2025. doi: 10.3748/wjg.v31.i37.112388
Published online Oct 7, 2025. doi: 10.3748/wjg.v31.i37.112388
Recent advances in the diagnosis of celiac disease
Zhen Wang, Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Qi Wu, Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Co-corresponding authors: Zhen Wang and Qi Wu.
Author contributions: Wang Z and Wu Q contributed to conceptualization, writing, reviewing, editing, and made equal contributions as co-corresponding authors.
Supported by National Natural Science Foundation of China, No. 82300451; and Research Foundation of Wuhan Union Hospital, No. 2022xhyn050.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Zhen Wang, MD, PhD, Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Jianghan District, Wuhan 430022, Hubei Province, China.
Received: July 28, 2025
Revised: August 25, 2025
Accepted: September 5, 2025
Published online: October 7, 2025
Processing time: 61 Days and 20.7 Hours
Revised: August 25, 2025
Accepted: September 5, 2025
Published online: October 7, 2025
Processing time: 61 Days and 20.7 Hours
Core Tip
Core Tip: Celiac disease is a chronic immune-mediated enteropathy triggered by dietary gluten in genetically predisposed individuals, causing systemic inflammation through malabsorption and extra-intestinal manifestations While duodenal biopsy is the gold standard, serum antibodies against tissue transglutaminase are crucial complementary tools. This editorial evaluates serum biomarkers as vital tools for diagnosis and moni