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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2025; 31(37): 110942
Published online Oct 7, 2025. doi: 10.3748/wjg.v31.i37.110942
Published online Oct 7, 2025. doi: 10.3748/wjg.v31.i37.110942
Epidemiology of dyspepsia and esophagogastroduodenoscopic findings in the era of Helicobacter pylori eradication
Suguo Suzuki, Takeshi Kanno, Tomoyuki Koike, Yutaka Hatayama, Yohei Ogata, Masahiro Saito, Waku Hatta, Kaname Uno, Akira Imatani, Atsushi Masamune, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 9808575, Miyagi, Japan
Takeshi Kanno, Research and Development Division of Career Education for Medical Professionals, Medical Education Center, Jichi Medical University, Shimotsuke 3290498, Tochigi, Japan
Takashi Chiba, Kiyotaka Asanuma, Katsuaki Kato, Cancer Screening Center, Miyagi Cancer Society, Sendai 9800011, Miyagi, Japan
Author contributions: Suzuki S, Kanno T, and Koike T contributed to conceptualization; Suzuki S and Kanno T contributed to methodology and writing - original draft preparation; Suzuki S, Kanno T, and Chiba T contributed to formal analysis and investigation; Koike T, Chiba T, Asanuma K, Kato K, Hatayama Y, Ogata Y, Saito M, Hatta W, Uno K, Imatani A, and Masamune A contributed to writing - review and editing; Koike T and Masamune A contributed to supervision.
Institutional review board statement: This study was conducted according to the principles of the Declaration of Helsinki (as revised in Brazil in 2013) and approved by the Ethics Committees of the Miyagi Cancer Society (Approval No. 3-2206).
Informed consent statement: Written informed consent was not obtained, as the study involved the secondary use of anonymized data collected through a municipal gastric cancer screening program. Personal identifiers were removed before analysis. Information regarding the study was made publicly available on the institutional website, and an opt-out option was provided to protect participants’ rights.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Due to the nature of this research, participants of this study did not agree for their data to be shared publicly, so supporting data is not available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Takeshi Kanno, MD, PhD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 9808575, Miyagi, Japan. kanno.takeshi@med.tohoku.ac.jp
Received: June 24, 2025
Revised: July 23, 2025
Accepted: August 25, 2025
Published online: October 7, 2025
Processing time: 96 Days and 2.3 Hours
Revised: July 23, 2025
Accepted: August 25, 2025
Published online: October 7, 2025
Processing time: 96 Days and 2.3 Hours
Core Tip
Core Tip: We analyzed over 23000 adults undergoing endoscopic gastric cancer screening in Japan to assess dyspepsia prevalence across Helicobacter pylori infection statuses. Dyspepsia was most prevalent (28.7%) in the post-eradication and non-infected groups, compared to 25.8% in the currently infected group. Younger age, female sex, peptic ulcers, erosive esophagitis, and post-eradication status were independently associated with dyspepsia. Despite extensive endoscopic evaluation, over 90% of cases had no organic findings. These results highlight the evolving nature of dyspepsia and its persistence in the post-Helicobacter pylori era.