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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2025; 31(35): 109808
Published online Sep 21, 2025. doi: 10.3748/wjg.v31.i35.109808
Published online Sep 21, 2025. doi: 10.3748/wjg.v31.i35.109808
Comparative evaluation of three traditional herbal formulas on gastrointestinal motility in a mouse model of cold stress-induced dyspepsia
Jing-Hua Wang, Institute of Oriental Medicine, Dongguk University, Goyang 10326, South Korea
Song-Yi Han, Liangliang Wu, Rehabilitation Medicine of Korean Medicine, Dongguk University, Goyang 10326, South Korea
Uijeong Han, Si-Kyung Cho, Department of Biological and Environmental Science, Dongguk University, Goyang 10326, South Korea
Chan-Woong Park, Young-Won Chin, Natural Product Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, South Korea
Mi Young Lim, Precision Nutrition Research Group, Korea Food Research Institute, Wanju 55365, South Korea
Hojun Kim, Division of Rehabilitation Medicine of Korean Medicine, Department of Oriental Rehabilitation Medicine, Dongguk University, Ilsan Hospital, Goyang 10326, South Korea
Author contributions: Wang JH contributed to writing the original draft, methodology, formal analysis, and data curation; Han SY and Cho SK contributed to validation, methodology, data curation; Wu L contributed to methodology, formal analysis; Han U contributed to formal analysis and data curation; Park CW contributed to visualization, validation; Chin YW contributed to validation, formal analysis; Lim MY contributed to writing-review and editing; Kim H contributed to writing-review and editing, supervision, project administration, funding acquisition, conceptualization.
Supported by the National Research Foundation of Korea, No. 2022M3A9E4017033.
Institutional animal care and use committee statement: The animal experimental protocol was approved by the Institutional Animal Ethics Committee of Dongguk University (No. IACUC-2024-03260; approval date: 8 April 2024).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: Data will be made available on request at kimklar@dongguk.ac.kr.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hojun Kim, PhD, Professor, Division of Rehabilitation Medicine of Korean Medicine, Department of Oriental Rehabilitation Medicine, Dongguk University, Ilsan Hospital, 27 Dongguk-ro, Goyang 10326, South Korea. kimklar@dongguk.ac.kr
Received: May 23, 2025
Revised: June 24, 2025
Accepted: August 15, 2025
Published online: September 21, 2025
Processing time: 119 Days and 9.1 Hours
Revised: June 24, 2025
Accepted: August 15, 2025
Published online: September 21, 2025
Processing time: 119 Days and 9.1 Hours
Core Tip
Core Tip: This study systematically compared the therapeutic effects of three classical herbal formulas [Pyeongwi-san (PS), Shihosogan-tang, and Yijung-tang] in a mouse model of cold stress-induced dyspepsia. Among them, PS was the most effective in restoring gastrointestinal motility, enhancing gastric acid secretion and upregulating digestive enzymes gene expression, and modulating serotonin, short-chain fatty acids, bile acid receptors, and glucagon-like peptide-1 signaling. These findings elucidate the mechanisms of PS’s superior efficacy and strongly support its clinical application in treating cold-induced gastrointestinal dysfunction.