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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2025; 31(33): 107408
Published online Sep 7, 2025. doi: 10.3748/wjg.v31.i33.107408
Published online Sep 7, 2025. doi: 10.3748/wjg.v31.i33.107408
Noninvasive model based on liver and spleen stiffness for predicting clinical decompensation in patients with cirrhosis
Long-Bao Yang, Xin Gao, Yong Li, Lei Dong, Xin-Di Huang, Xiao She, Dan-Yang Zhang, Qian-Wen Zhang, Chen-Yu Liu, Yan Wang, Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Meng Xu, Department of General Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Shu-Ting Fan, Department of Supply, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Co-first authors: Long-Bao Yang and Xin Gao.
Author contributions: Yang LB and Gao X contributed equally to this work as co-first authors; Xu M, Li Y, and Dong L designed the research study; Liu CY and Gao X performed the research; Huang XD, She X, and Zhang DY contributed new reagents and analytic tools; Zhang QW, Fan ST, and Wang Y analyzed the data and wrote the manuscript; all the authors have read and approved the final manuscript.
Supported by Xi’an Science and Technology Plan, No. 23YXYJ0172.
Institutional review board statement: The study was approved by the Ethics Committee of The Second Affiliated Hospital of Xi’an Jiaotong University, No. 2017-445.
Informed consent statement: The informed consent was waived because of its retrospective nature.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The dataset generated and analyzed during the current study is available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Wang, MD, Assistant Professor, Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 of Xiwu Road, Xi’an 710004, Shaanxi Province, China. sarrye@163.com
Received: March 23, 2025
Revised: May 13, 2025
Accepted: August 12, 2025
Published online: September 7, 2025
Processing time: 162 Days and 23 Hours
Revised: May 13, 2025
Accepted: August 12, 2025
Published online: September 7, 2025
Processing time: 162 Days and 23 Hours
Core Tip
Core Tip: In this study, we developed a novel noninvasive predictive model using the liver stiffness measurement, spleen stiffness measurement, and spleen length diameter to evaluate the risk of clinical decompensation in individuals with viral cirrhosis. This is a new model that has not been reported before. Our findings indicate that it outperforms existing prediction models, demonstrating greater accuracy in identifying patients at risk. As a result, it holds significant potential for supporting clinical decision-making processes.