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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2025; 31(30): 109187
Published online Aug 14, 2025. doi: 10.3748/wjg.v31.i30.109187
Published online Aug 14, 2025. doi: 10.3748/wjg.v31.i30.109187
Unveiling Xuanshen decoction: A novel approach to combat slow transit constipation
Xing-Lin Zeng, Lian-Jun Zhu, Clinical Medicine College, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China
Xing-Lin Zeng, Yu-Jun Zhu, Department of General Surgery, Jiangbei Campus of The First Affiliated Hospital of Army Medical University, Chongqing 400020, China
Lian-Jun Zhu, Yu Zhang, Xiang-Dong Yang, Department of Colorectal and Anal Surgery, Chengdu Anorectal Hospital, Chengdu 610015, Sichuan Province, China
Co-corresponding authors: Xiang-Dong Yang and Yu-Jun Zhu.
Author contributions: Zeng XL, Zhu LJ, and Zhang Y performed the experiments; Zeng XL, Yang XD, and Zhu YJ designed the research study contributed to the materials/reagents/analysis tools, analyzed the data, and wrote the manuscript; Zhu YJ and Yang XD contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors have read and approved the final manuscript.
Supported by the 2024 Hospital Innovation Talent Cultivation Fund Project, No. 2024YGKT12.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Guizhou University of Traditional Chinese Medicine, approval No. 20220065.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: Study data can be obtained by contacting the corresponding author with appropriate justification.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Jun Zhu, MD, Associate Chief Physician, Department of General Surgery, Jiangbei Campus of The First Affiliated Hospital of Army Medical University, No. 29 Jianxin East Road, Jiangbei District, Chongqing 400020, China. merezyj@163.com
Received: May 6, 2025
Revised: June 9, 2025
Accepted: July 21, 2025
Published online: August 14, 2025
Processing time: 97 Days and 18.7 Hours
Revised: June 9, 2025
Accepted: July 21, 2025
Published online: August 14, 2025
Processing time: 97 Days and 18.7 Hours
Core Tip
Core Tip: There are limited drugs available to treat slow transit constipation (STC). Xuanshen decoction is a traditional Chinese medicine formulation that can effectively treat STC. In this study, Xuanshen decoction significantly alleviated the symptoms of STC in rats. Xuanshen decoction promoted the expression of key proteins in the phosphoinositide 3-kinase/pro