Clinical Trials Study
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World J Gastroenterol. Jan 21, 2025; 31(3): 99833
Published online Jan 21, 2025. doi: 10.3748/wjg.v31.i3.99833
C-X-C chemokine receptor type 5+CD8+ T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferon-alpha treatment
Zhen-Yu Xu, Zhong-Shang Dai, Guo-Zhong Gong, Min Zhang
Zhen-Yu Xu, Zhong-Shang Dai, Guo-Zhong Gong, Department of Infectious Diseases, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Min Zhang, Institute of Hepatology and Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Co-first authors: Zhen-Yu Xu and Zhong-Shang Dai.
Author contributions: Xu ZY and Dai ZS collected data, drafted the manuscript, and critically revised the manuscript; Zhang M supervised the study; Gong GZ designed the study and revised the manuscript. All authors approved the final version of the manuscript. Xu ZY and Dai ZS contributed equally to this work as co-first authors.
Supported by Changsha Science and Technology Program, No. kq2022397; Natural Science Foundation of Hunan Province (Departmental Joint Fund), No. 2023JJ60440; Research Program of Health Commission of Hunan Province, No. 202303088786; Clinical Medical Research Center for Viral Hepatitis of Hunan Province, No. 2023SK4009; and the Scientific Research Program of FuRong Laboratory, No. 2023SK2108.
Institutional review board statement: The research was approved by the Ethics Committee of the Second Xiangya Hospital.
Clinical trial registration statement: This trial was registered at http://clinicaltrials.gov as (NCT01760122) on 03-01-2013.
Informed consent statement: All study participants or their legal guardian provided informed written consent regarding personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors disclose no conflicts.
Data sharing statement: The data that support the findings of this study are available in https://clinicaltrials.gov/study/NCT01760122?id=NCT01760122&rank=1.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Min Zhang, MD, Doctor, Institute of Hepatology and Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road Central, Changsha 410011, Hunan Province, China. zhangmin001@csu.edu.cn
Received: July 31, 2024
Revised: October 30, 2024
Accepted: November 15, 2024
Published online: January 21, 2025
Processing time: 141 Days and 17.1 Hours
Core Tip

Core Tip: This study highlights the pivotal role of C-X-C chemokine receptor type 5 (CXCR5)+CD8+ T cells in chronic hepatitis B (CHB) during pegylated interferon-alpha treatment. Our findings revealed that patients who achieved sustained serologic response exhibited higher baseline and treatment levels of CXCR5+CD8+ T cells, suggesting a connection between CXCR5 expression and IFN-induced antiviral immune responses. This research emphasizes the importance of CXCR5+CD8+ T cells as a potential biomarker for monitoring treatment efficacy in CHB patients.