Tomassoni DR, Schildkraut T, Ramachandran V, Cooke JC, Sawhney R. Cardiovascular risk assessment and predictors of cardiac decompensation after transjugular intrahepatic portosystemic shunt in patients with cirrhosis. World J Gastroenterol 2025; 31(27): 107740 [DOI: 10.3748/wjg.v31.i27.107740]
Corresponding Author of This Article
Rohit Sawhney, Associate Professor, Department of Gastroenterology, Eastern Health, 3 West, Building B, Box Hill Hospital, 8 Arnold Street, Box Hill, Melbourne 3128, Victoria, Australia. rohit.sawhney@easternhealth.org.au
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 21, 2025; 31(27): 107740 Published online Jul 21, 2025. doi: 10.3748/wjg.v31.i27.107740
Cardiovascular risk assessment and predictors of cardiac decompensation after transjugular intrahepatic portosystemic shunt in patients with cirrhosis
Davide R Tomassoni, Tamar Schildkraut, Vivekananda Ramachandran, Jennifer C Cooke, Rohit Sawhney
Davide R Tomassoni, Department of General Medicine, Eastern Health, Melbourne 3128, Victoria, Australia
Tamar Schildkraut, Rohit Sawhney, Department of Gastroenterology, Eastern Health, Melbourne 3128, Victoria, Australia
Vivekananda Ramachandran, Department of Radiology, Eastern Health, Melbourne 3128, Victoria, Australia
Jennifer C Cooke, Department of Cardiology, Eastern Health, Melbourne 3128, Victoria, Australia
Jennifer C Cooke, Rohit Sawhney, Eastern Health Clinical School, Monash University, Melbourne 3128, Victoria, Australia
Author contributions: Tomassoni DR was the predominant writer, performed literature search, extraction, evaluation and synthesis; Schildkraut T was secondary author, co-evaluator for literature reviewed, edited the article, provided assistance with producing figures; Ramachandran V provided radiological expertise, assistant editor; Cooke JC provided cardiology expertise, assistance with formulation of figure 4, assistant editor; Sawhney R provided research oversight, key gastroenterology consultation and major structuring of review as well as editing.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rohit Sawhney, Associate Professor, Department of Gastroenterology, Eastern Health, 3 West, Building B, Box Hill Hospital, 8 Arnold Street, Box Hill, Melbourne 3128, Victoria, Australia. rohit.sawhney@easternhealth.org.au
Received: March 30, 2025 Revised: May 16, 2025 Accepted: July 1, 2025 Published online: July 21, 2025 Processing time: 115 Days and 9.4 Hours
Core Tip
Core Tip: Diastolic dysfunction, particularly when defined using American Society of Echocardiography criteria, consistently correlates with post-transjugular intrahepatic portosystemic shunt (TIPS) heart failure. N-terminal pro-B-type natriuretic peptide ≥ 125 pg/mL, clinical history and examination, 12-lead electrocardiography, transthoracic echocardiography can improve pre-TIPS risk stratification, optimise patient selection, and enable early cardiac optimisation. Employing additional tools, such as the heart failure with preserved ejection fraction score and left-atrial strain imaging may further characterise cardiac dysfunction however, requires further validation. Future research should clarify the role of cardiac magnetic resonance imaging and precision medicine in this cohort.
