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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2025; 31(23): 106949
Published online Jun 21, 2025. doi: 10.3748/wjg.v31.i23.106949
Published online Jun 21, 2025. doi: 10.3748/wjg.v31.i23.106949
Celastrol alleviates esophageal stricture in rats by inhibiting NLR family pyrin domain containing 3 activation
Miao-Xin Zhang, Chi Wu, Wei Tian, Ning-Hui Zhao, Mei Liu, Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Xin-Xia Feng, Pan-Pan Lu, Qiang Ding, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Author contributions: Liu M, Lu PP, and Ding Q designed the research study; Zhang MX, Wu Chi, Feng XX, Tian W, and Zhao NH performed the research.
Supported by National Natural Science Foundation of China, No. 82002609.
Institutional review board statement: The protocols were approved by the Ethics Committee of Tongji Medical College of Huazhong University of Science and Technology, No. S167.
Institutional animal care and use committee statement: All animal experimental procedures were approved by the Institutional Animal Care and Use Committee of Huazhong University of Science and Technology, No. 4016.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mei Liu, MD, PhD, Professor, Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Road, Wuhan 430030, Hubei Province, China.
Received: March 12, 2025
Revised: April 23, 2025
Accepted: May 26, 2025
Published online: June 21, 2025
Processing time: 101 Days and 5.7 Hours
Revised: April 23, 2025
Accepted: May 26, 2025
Published online: June 21, 2025
Processing time: 101 Days and 5.7 Hours
Core Tip
Core Tip: NLR family pyrin domain containing 3 (NLRP3) and interleukin-1β are increased in the endoscopic submucosal dissection resection bed of patients with esophageal neoplasms. Celastrol (CEL) prevented esophageal stricture in rats, and the effects were comparable to the positive control, prednisolone. Thioredoxin reductase 1 (TXNRD1) was increased by CEL in lipopolysaccharide plus adenosine triphosphate stimulated primary rat esophageal fibroblasts. Independent of its effect on reactive oxygen species, TXNRD1 interacts with NLRP3 and promotes its ubiquitination.