Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2025; 31(23): 103848
Published online Jun 21, 2025. doi: 10.3748/wjg.v31.i23.103848
Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model
Bing Wang, Jia-Yi Ge, Jia-Ni Wu, Jia-Huan Xu, Xiao-Hua Cao, Na Chang, Xiang Zhou, Peng-Bo Jing, Xing-Jun Liu, Yong Wu
Bing Wang, Yong Wu, Department of Anesthesiology, The First People’s Hospital of Lianyungang, Lianyungang 222000, Jiangsu Province, China
Jia-Yi Ge, Jia-Ni Wu, Jia-Huan Xu, Xiao-Hua Cao, Na Chang, Xiang Zhou, Peng-Bo Jing, Xing-Jun Liu, School of Pharmacy, Nantong University, Nantong 226019, Jiangsu Province, China
Co-corresponding authors: Xing-Jun Liu and Yong Wu.
Author contributions: Wang B and Liu XJ designed and coordinated the study; Wang B, Ge JY, Wu JN, Xu JH, Cao XH, Chang N, Zhou X, and Jing PB performed the experiments, acquired and analyzed data; Wang B, Liu XJ, and Wu Y interpreted the data; Liu XJ and Wu Y contributed equally as co-corresponding authors; Wang B and Wu Y wrote the manuscript; and all authors approved the final version of the article.
Supported by Hansoh Foundation of Lianyungang, No. QN1913.
Institutional animal care and use committee statement: All animal studies were performed based on relevant ethical guidelines of the International Association for the Study of Pain and approved by the Committees of the Use of Laboratory Animals of Nantong University (Approval No. S20220217-016).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong Wu, MD, Chief Physician, Department of Anesthesiology, The First People’s Hospital of Lianyungang, No. 6 Zhenhua East Street, Lianyungang 222000, Jiangsu Province, China. 18961325621@163.com
Received: December 4, 2024
Revised: March 30, 2025
Accepted: May 30, 2025
Published online: June 21, 2025
Processing time: 200 Days and 1.7 Hours
Core Tip

Core Tip: Currently the mechanism underlying abdominal pain associated with chronic pancreatitis (CP) is not well understood. Utilizing dibutyltin dichloride-induced CP mouse model, it was found that the nociceptor-expressing endothelin A receptor (ETAR) is essential for the development of mechanical hypersensitivity following dibutyltin dichloride treatment. ETAR may contribute to this through regulating calcitonin gene-related peptide expression and activating immune cells. Therefore, targeting ETAR-dependent endothelin signaling in nociceptive sensory neurons may be a potential therapeutic approach for treating CP patients.