Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/NFAT3 mechanism

doi:10.3748/wjg.v31.i20.105554

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May 28, 2025 (publication date) through May 28, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. May 28, 2025; 31(20): 105554
Published online May 28, 2025. doi: 10.3748/wjg.v31.i20.105554

Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/NFAT3 mechanism

Shi-Yi Lyu, Wang Xiao, Yan-Jing Chen, Qiu-Ling Liao, Ye-Yu Cai, Cheng Yu, Jia-Yi Liu, Huan Liu, Min-Ping Zhang, Yu-Lu Ren, Qi-Ling Yu, Yi-Ming Qi, En-Hua Xiao, Yong-Heng Luo

Shi-Yi Lyu, Qiu-Ling Liao, Ye-Yu Cai, Cheng Yu, Yu-Lu Ren, Qi-Ling Yu, Yi-Ming Qi, En-Hua Xiao, Yong-Heng Luo, Department of Radiology, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China

Wang Xiao, Department of Gastrointestinal Surgery, Yiyang Central Hospital, Yiyang 413099, Hunan Province, China

Yan-Jing Chen, Department of Radiology, Peking University Third Hospital, Beijing 100083, China

Jia-Yi Liu, Department of Oncology, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China

Huan Liu, Department of Radiology, Second Affiliated Hospital, South China University, Hengyang 421001, Hunan Province, China

Min-Ping Zhang, Department of Ultrasound, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China

En-Hua Xiao, Yong-Heng Luo, Department of Radiology, Clinical Research Center for Medical Imaging, Changsha 410011, Hunan Province, China

Co-corresponding authors: En-Hua Xiao and Yong-Heng Luo.

Author contributions: Lyu SY, Luo YH and Xiao EH designed and coordinated the study; Xiao W, Liao QL, Chen YJ and Cai YY conducted the literature research and created the tables and plots; Yu C, Liu JY, Liu H and Zhang MP performed the experiments; Ren YL, Yu QL and Qi YM acquired and analyzed data; Lyu SY and Luo YH drafted the manuscript; Luo YH and Xiao EH jointly supervised this work; All authors have read and agreed to the published version of the manuscript.

Supported by the Health Research Foundation of Hunan Provincial Health Commission, No. W20243192; Natural Science Foundation of Changsha, No. kq2403086; National Natural Science Foundation of China, No. 81571784; and Hunan Provincial Health Commission Hunan Provincial High-level Health Talent Major Scientific Research Project, No. R2023022.

Institutional review board statement: This study does not involve any human experiments.

Institutional animal care and use committee statement: The study protocol was approved by the Animal Care and Use Committee of Second Xiangya Hospital of Central South University (approval number: 20230520).

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Yong-Heng Luo, PhD, Doctor, Department of Radiology, Second Xiangya Hospital of Central South University, No. 139 Renming Middle Road, Changsha 410011, Hunan Province, China. luoyongheng@csu.edu.cn

Received: January 27, 2025
Revised: April 4, 2025
Accepted: May 15, 2025
Published online: May 28, 2025
Processing time: 122 Days and 3.1 Hours

Core Tip

Core Tip: This study explored zebularine’s role in liver fibrosis. Given that hepatic stellate cell activation drives fibrosis and zebularine’s potential via calcineurin/NFAT3, it aimed to clarify its mechanism and efficacy using multiparametric magnetic resonance imaging (MRI). In vitro and in vivo tests showed zebularine regulated genes, inhibited the pathway, and reduced fibrosis, with MRI validating its efficacy.