Advances and challenges in diagnosing and managing adult autoimmune enteropathy

doi:10.3748/wjg.v31.i2.99118

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Jan 14, 2025 (publication date) through Feb 4, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2025; 31(2): 99118
Published online Jan 14, 2025. doi: 10.3748/wjg.v31.i2.99118

Advances and challenges in diagnosing and managing adult autoimmune enteropathy

Grigorios Christodoulidis, Sara E Agko, Marina N Kouliou, Konstantinos E Koumarelas, Dimitris Zacharoulis

Grigorios Christodoulidis, Marina N Kouliou, Department of General Surgery, University Hospital of Larissa, Larissa 41110, Greece

Sara E Agko, Department of Intensive Care Unit, Asklepios Paulinen Clinic Wiesbaden, Wiesbaden 65197, Germany

Konstantinos E Koumarelas, Department of Emergency Medicine, General Hospital of Larissa, Larissa 41221, Greece

Dimitris Zacharoulis, Department of Surgery, University Hospital of Larissa, Larissa 41334, Greece

Author contributions: Christodoulidis G, Agko SE, Koumarelas KE, Kouliou MN and Zacharoulis D contributed to this paper; Christodoulidis G designed the overall concept and outline of the manuscript; Christodoulidis G, Agko SE, Koumarelas KE, Kouliou MN and Zacharoulis D contributed to the discussion and design of the manuscript, writing and editing the manuscript, and review of the literature.

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Grigorios Christodoulidis, PhD, Executive Associate Editor-in-Chief, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece. gregsurg@yahoo.gr

Received: July 14, 2024
Revised: November 1, 2024
Accepted: November 14, 2024
Published online: January 14, 2025
Processing time: 156 Days and 23.4 Hours

Core Tip

Core Tip: Autoimmune enteropathy (AIE) is a rare, immune-mediated disorder predominantly affecting children, characterized by chronic diarrhea, malabsorption, vomiting, weight loss, and villous atrophy. Adults can also be affected, complicating diagnosis and treatment due to symptom overlap with other gastrointestinal disorders. Key diagnostic criteria include small bowel villous atrophy, lack of response to dietary restrictions, presence of anti-enterocyte antibodies, and a predisposition to autoimmunity without severe immunodeficiency. Further research is needed to elucidate the pathogenesis, disease progression and long-term outcomes of AIE.