Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2025; 31(2): 101620
Published online Jan 14, 2025. doi: 10.3748/wjg.v31.i2.101620
Human leukocyte antigen and donor-specific antibodies in liver transplantation
Qimudesiren, Sha-Na Chen, Li-Ren Qian
Qimudesiren, School of Clinical Medicine, Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia Autonomous Region, China
Sha-Na Chen, Department of Hematology, International Mongolian Hospital of Inner Mongolia, Hohhot 010065, Inner Mongolia Autonomous Region, China
Li-Ren Qian, Senior Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing 100071, China
Li-Ren Qian, The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Co-corresponding authors: Sha-Na Chen and Li-Ren Qian.
Author contributions: Qimudesiren contributed to manuscript drafting and writing; Chen SN contributed to critical revision; Qian LR contributed to conception and design.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Ren Qian, MD, Senior Department of Hematology, The Fifth Medical Center of PLA General Hospital, No. 8 Dongda Street, Haidian District, Beijing 100071, China. qlr2007@126.com
Received: September 20, 2024
Revised: October 26, 2024
Accepted: November 21, 2024
Published online: January 14, 2025
Processing time: 88 Days and 14.6 Hours
Core Tip

Core Tip: Donor-specific antibodies (DSAs), particularly those against human leukocyte antigen (HLA) DQ loci, significantly affect rejection risk and graft survival in pediatric liver transplantation. The presence of DSAs is linked to increased rates of both acute and chronic rejection, which impacts long-term graft viability. These findings highlight the importance of improved HLA and DSA monitoring and management to improve long-term outcomes in pediatric liver transplant recipients.