Decoding prognosis in dengue-induced hepatitis: Model for end-stage liver disease vs albumin-bilirubin for predicting liver failure and survival

doi:10.3748/wjg.v31.i16.102778

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Apr 28, 2025 (publication date) through Apr 27, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2025; 31(16): 102778
Published online Apr 28, 2025. doi: 10.3748/wjg.v31.i16.102778

Decoding prognosis in dengue-induced hepatitis: Model for end-stage liver disease vs albumin-bilirubin for predicting liver failure and survival

Linda Galasso, Giorgio Esposto, Irene Mignini, Maria Elena Ainora, Maria Assunta Zocco

Linda Galasso, Giorgio Esposto, Irene Mignini, Maria Elena Ainora, Maria Assunta Zocco, Centro Malattie Apparato Digerente, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy

Author contributions: Zocco MA contributed to the conceptualization; Galasso L, Esposto G contributed to writing and original draft; Galasso L, Esposto G, Mignini I contributed to writing, review and editing; Ainora ME, Zocco MA contributed to the supervision.

Conflict-of-interest statement: Authors declare no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Maria Assunta Zocco, MD, PhD, Professor, Centro Malattie Apparato Digerente, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Gemelli 1, Rome 00168, Italy. mariaassunta.zocco@unicatt.it

Received: October 29, 2024
Revised: March 9, 2025
Accepted: March 17, 2025
Published online: April 28, 2025
Processing time: 180 Days and 19.2 Hours

Core Tip

Core Tip: Although dengue infection can result in liver injury, it rarely manifests as dengue-induced severe hepatitis (DISH). Since DISH can rapidly progress to acute liver failure, it appears crucial to early identify patients at risk in order to improve medical care and prognosis. In this context, liver specific prognostic scores, as model for end-stage liver disease or easy-albumin-bilirubin, proved effective when combined.