Prognostic value of the triglyceride-glucose index in advanced gastric cancer: A call for further exploration

doi:10.3748/wjg.v31.i15.104574

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Apr 21, 2025 (publication date) through Apr 18, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastroenterol. Apr 21, 2025; 31(15): 104574
Published online Apr 21, 2025. doi: 10.3748/wjg.v31.i15.104574

Prognostic value of the triglyceride-glucose index in advanced gastric cancer: A call for further exploration

Hong-Jie Meng, Yi Mao, De-Qing Zhao, Sheng-Guang Shi

Hong-Jie Meng, Yi Mao, De-Qing Zhao, Sheng-Guang Shi, Department of Gastrointestinal Surgery Ward, Zhuji People’s Hospital, Zhuji 311800, Zhejiang Province, China

Author contributions: Meng HJ conceptualization, writing, reviewing and editing; Mao Y methodology and formal analysis; Zhao DQ and Shi SG supervision and writing of the original draft; Meng HJ, Mao Y, Zhao DQ, and Shi SG participated in drafting the manuscript and have read it, and all authors thoroughly reviewed and endorsed the final manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Hong-Jie Meng, MD, Associate Chief Physician, Senior Researcher, Department of Gastrointestinal Surgery Ward, Zhuji People’s Hospital, No. 9 Jianmin Road, Taozhu Street, Zhuji 311800, Zhejiang Province, China. mhj7768@163.com

Received: December 25, 2024
Revised: March 9, 2025
Accepted: March 17, 2025
Published online: April 21, 2025
Processing time: 114 Days and 22 Hours

Core Tip

Core Tip: The triglyceride-glucose (TyG) index, a surrogate marker for insulin resistance, has emerged as a potential prognostic factor in advanced gastric cancer. Recent findings suggest that a high TyG index correlates with improved overall survival and progression-free survival in patients undergoing immunotherapy combined with chemotherapy. This highlights the clinical relevance of insulin sensitivity in modulating treatment efficacy. Further multicenter studies are essential to validate its prognostic value across diverse populations and to explore underlying mechanisms. Integrating the TyG index into comprehensive prognostic models may optimize treatment strategies and improve patient outcomes in advanced gastric cancer.