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World J Gastroenterol. Apr 7, 2025; 31(13): 104671
Published online Apr 7, 2025. doi: 10.3748/wjg.v31.i13.104671
Endoplasmic reticulum stress in gut inflammation: Implications for ulcerative colitis and Crohn’s disease
Ting Zheng, Kai-Yue Huang, Xu-Dong Tang, Feng-Yun Wang, Lin Lv
Ting Zheng, Kai-Yue Huang, Graduate School, China Academy of Chinese Medical Sciences, Beijing 100091, China
Xu-Dong Tang, Feng-Yun Wang, Lin Lv, Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China
Author contributions: Zheng T reviewed the literature and wrote the first draft of the paper; Huang KY contributed to searching the literature and edited it; Wang FY contributed to revising the paper; Tang XD conceived the idea and edited it; Lv L contributed to writing the paper, and edited it extensively.
Supported by the National Natural Science Foundation of China, No. 81873297; the Fundamental Research Funds for the Central Public Welfare Research Institutes, No. ZZ13-YQ-006; China Academy of Chinese Medical Sciences Innovation Fund, No. CI2021A01003; and the Hospital Capability Enhancement Project of Xiyuan Hospital, China Academy of Chinese Medical Sciences, No. XYZX0303-07.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin Lv, MD, Associate Chief Physician, Institute of Digestive Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, No. 1 Xiyuan Playground, Haidian District, Beijing 100091, China. lushangshitou@qq.com
Received: December 28, 2024
Revised: February 20, 2025
Accepted: March 13, 2025
Published online: April 7, 2025
Processing time: 96 Days and 3.3 Hours
Core Tip

Core Tip: Endoplasmic reticulum stress, as an important cell - responsive protective mechanism, plays a crucial role in maintaining the stability of the intracellular environment of intestinal cells in the highly prevalent inflammatory bowel disease. If the mechanisms by which it plays a key role can be accurately analyzed, there is great hope of opening up a new path for the treatment of inflammatory bowel disease.