Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2025; 31(12): 102423
Published online Mar 28, 2025. doi: 10.3748/wjg.v31.i12.102423
Published online Mar 28, 2025. doi: 10.3748/wjg.v31.i12.102423
To activate a G protein-coupled receptor permanently with cell surface photodynamic action in the gastrointestinal tract
Zong-Jie Cui, Department of Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China
Zong-Jie Cui, The Ministry of Education Laboratory for Cell Proliferation and Regulation, College of Life Sciences, Beijing Normal University, Beijing 100875, China
Author contributions: Cui ZJ conceived the idea of this review, analyzed the relevant literature, wrote the initial drafts of this paper, wrote and approved the final submitted version of this review.
Supported by the National Natural Science Foundation of China, No. 32271278 and No. 31971170.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zong-Jie Cui, PhD, Professor, Department of Biology, College of Life Sciences, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China. zjcui@bnu.edu.cn
Received: October 18, 2024
Revised: January 14, 2025
Accepted: January 17, 2025
Published online: March 28, 2025
Processing time: 160 Days and 5.8 Hours
Revised: January 14, 2025
Accepted: January 17, 2025
Published online: March 28, 2025
Processing time: 160 Days and 5.8 Hours
Core Tip
Core Tip: G protein-coupled receptors (GPCR) are a large group of functional proteins, whose ligands account for a large proportion of clinical drugs. Important as GPCR may be, their ligand-independent pharmacology is poorly investigated. This minireview shows that the A-class GPCR cholecystokinin 1 receptor, predominantly expressed in pancreatic acini, could be activated permanently by singlet oxygen in photodynamic action. Three lines of evidence regarding mechanisms of photodynamic activation is presented. Clues suggest that permanent photodynamic activation of other GPCR and other functional proteins are possible, permanent photodynamic activation may be a general principle, both in gastrointestinal tract and elsewhere.