©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2024; 30(41): 4490-4495
Published online Nov 7, 2024. doi: 10.3748/wjg.v30.i41.4490
Published online Nov 7, 2024. doi: 10.3748/wjg.v30.i41.4490
Abnormally activated wingless/integrated signaling modulates tumor-associated macrophage polarization and potentially promotes hepatocarcinoma cell growth
Wei-Lu Wang, Paul Kwong Hang Tam, Yan Chen, School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau 999078, China
Author contributions: Wang WL and Chen Y wrote this article; Tam PKH and Chen Y revised this editorial and provided funding support. All authors have read and approved the final manuscript.
Supported by Macau Science and Technology Development Fund , No. 0086/2022/A and No. 0097/2022/A2 .
Conflict-of-interest statement: Tam PKH and Chen Y have received research funding from Macau Science and Technology Development Fund.
Corresponding author: Yan Chen, PhD, Assistant Professor, School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Praia Park Block R Coloane Macau, Macau 999078, China. chenyan@must.edu.mo
Received: August 1, 2024
Revised: September 19, 2024
Accepted: October 9, 2024
Published online: November 7, 2024
Processing time: 82 Days and 21.6 Hours
Revised: September 19, 2024
Accepted: October 9, 2024
Published online: November 7, 2024
Processing time: 82 Days and 21.6 Hours
Core Tip
Core Tip: This paper sheds light on the role of abnormally activated wingless/integrated signaling pathway as an M2 tumor-associated macrophage polarization promoter and potential target for promoting hepatocarcinoma cell growth and migration. We also comment on the article by Huang et al. Finally, we highlight areas in the study by Huang et al that require further research, providing guidance and new directions for similar relevant studies.