Trypsin in pancreatitis: The culprit, a mediator, or epiphenomenon?
Anna S Gukovskaya, Markus M Lerch, Julia Mayerle, Matthias Sendler, Baoan Ji, Ashok K Saluja, Fred S Gorelick, Ilya Gukovsky
Anna S Gukovskaya, Ilya Gukovsky, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90073, United States
Anna S Gukovskaya, Ilya Gukovsky, Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, United States
Markus M Lerch, Department of Medicine, Ludwig Maximilian University Hospital, Munich 81377, Germany
Julia Mayerle, Department of Medicine II, Ludwig Maximilian University of Munich, Munich 81377, Germany
Matthias Sendler, Department of Medicine A, University of Greifswald, Greifswald 17475, Germany
Baoan Ji, Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, United States
Ashok K Saluja, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, United States
Fred S Gorelick, Departments of Cell Biology and Internal Medicine, Yale University School of Medicine and VA West Haven, New Haven, CT 06519, United States
Co-corresponding authors: Anna S Gukovskaya and Ilya Gukovsky.
Author contributions: Gukovskaya AS and Gukovsky I conceived the review, designed its structure, created the tables, and wrote the first draft; Gukovskaya AS, Gorelick FS, and Gukovsky I edited the manuscript and created the figures; Gukovskaya AS, Lerch MM, Mayerle J, Sendler M, Ji BA, Saluja AK, Gorelick FS, and Gukovsky I provided significant edits to the text in multiple rounds of discussion; and all authors read and approved the final manuscript. Gukovskaya AS and Gukovsky I are co-corresponding authors, having contributed equally to all aspects of this review preparation.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Anna S Gukovskaya, AGAF, DSc, PhD, Director, Full Professor, Senior Scientist, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, 11301 Wilshire Blvd, Bldg. 258/340, Los Angeles, CA 90073, United States.
agukovsk@ucla.edu
Received: April 23, 2024
Revised: June 19, 2024
Accepted: July 16, 2024
Published online: November 7, 2024
Processing time: 183 Days and 2.6 Hours
