Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 28, 2024; 30(40): 4399-4403
Published online Oct 28, 2024. doi: 10.3748/wjg.v30.i40.4399
Inhibition of M2 tumor-associated macrophages polarization by modulating the Wnt/β-catenin pathway as a possible liver cancer therapy method
Vladislav V Tsukanov, Julia L Tonkikh, Edward V Kasparov, Alexander V Vasyutin
Vladislav V Tsukanov, Julia L Tonkikh, Edward V Kasparov, Alexander V Vasyutin, Clinical Department of the Digestive System Pathology of Adults and Children, Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, Krasnoyarsk 660022, Russia
Author contributions: Tsukanov VV designed the overall concept and outline of the manuscript; Tonkikh JL, Kasparov EV and Vasyutin AV contributed to the discussion and design of the manuscript; Tsukanov VV, Tonkikh JL, Kasparov EV and Vasyutin AV contributed to the writing, and editing the manuscript, and review of literature.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vladislav V Tsukanov, DSc, MD, PhD, Full Professor, Clinical Department of the Digestive System Pathology of Adults and Children, Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, 3-G Partizan Zheleznyak St, Krasnoyarsk 660022, Russia. gastro@impn.ru
Received: August 14, 2024
Revised: September 9, 2024
Accepted: September 26, 2024
Published online: October 28, 2024
Processing time: 63 Days and 2 Hours
Core Tip

Core Tip: The editorial article is devoted to the possibility of drug inhibiting M2 tumor-associated macrophages polarization by modulating the Wnt/β-catenin pathway for suppressing liver cancer. The article by Chinese authors presented in the World Journal of Gastroenterology draws attention to this issue, in their work they showed that the use of a traditional Chinese medicine-Calculus bovis allows suppressing liver cancer growth in mice through this mechanism. This study is distinguished by its extremely promising and strategically new aim and a very impressive methodological level of research.