Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer

doi:10.3748/wjg.v30.i38.4211

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Oct 14, 2024 (publication date) through Oct 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2024; 30(38): 4211-4220
Published online Oct 14, 2024. doi: 10.3748/wjg.v30.i38.4211

Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer

Wei-Ling Zhang, Jing Sun, Rong-Fang Huang, Yi Zeng, Shu Chen, Xiao-Peng Wang, Jin-Hu Chen, Yun-Bin Chen, Chun-Su Zhu, Zai-Sheng Ye, You-Ping Xiao

Wei-Ling Zhang, Jing Sun, Yun-Bin Chen, You-Ping Xiao, Department of Radiology, Clinical Oncology School of Fujian Medical University & Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), Fuzhou 350014, Fujian Province, China

Rong-Fang Huang, Department of Pathology, Clinical Oncology School of Fujian Medical University & Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), Fuzhou 350014, Fujian Province, China

Yi Zeng, Shu Chen, Xiao-Peng Wang, Jin-Hu Chen, Zai-Sheng Ye, Department of Gastric Surgery, Clinical Oncology School of Fujian Medical University & Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), Fuzhou 350014, Fujian Province, China

Chun-Su Zhu, Department of Epidemiology, Clinical Oncology School of Fujian Medical University & Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), Fuzhou 350014, Fujian Province, China

Co-first authors: Wei-Ling Zhang and Jing Sun.

Co-corresponding authors: Zai-Sheng Ye and You-Ping Xiao.

Author contributions: Xiao YP, Ye ZS and Chen YB designed the study; Zhang WL, Sun J, Zeng Y, Chen S, Wang XP and Chen JH performed the research; Huang RF and Zhu CS contributed new reagents and analytical tools; Zhang WL, Sun J, Ye ZS and Xiao YP analyzed the data and wrote the manuscript. All authors have read and approved the final manuscript. Zhang WL and Sun J contributed equally to this work as co-first authors. Xiao YP and Ye ZS worked together to design the study and supervise the entire research process. Xiao YP is a radiologist who was responsible for conducting the spectral computed tomography examinations and managing the imaging database. Ye ZS is a surgical oncologist who was responsible for the clinical treatment of patients with gastric cancer and the management of the clinical database. Moreover, Xiao YP participated in the data analysis and manuscript writing and revision. Thus, Xiao YP and Ye ZS are co-corresponding authors for this paper.

Supported by Science and Technology Program of Fujian Province, No. 2021J01430; and Joint Funds for the Innovation of Science and Technology of Fujian Province, No. 2021Y9229.

Institutional review board statement: The study was reviewed and approved by the Fujian Cancer Hospital Institutional Review Board (No. K2022-152-01).

Clinical trial registration statement: Not applicable for this study is not a registered clinical trial.

Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.

Conflict-of-interest statement: The authors declare that there is no conflict of interest regarding the publication of this paper.

Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at xyp999@yeah.net.

CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: You-Ping Xiao, MD, Doctor, Department of Radiology, Clinical Oncology School of Fujian Medical University & Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), No. 420 Fuma Road, Jin'an District, Fuzhou 350014, Fujian Province, China. xyp999@yeah.net

Received: May 21, 2024
Revised: September 4, 2024
Accepted: September 18, 2024
Published online: October 14, 2024
Processing time: 131 Days and 8.8 Hours

Core Tip

Core Tip: Anti-HER2 receptor is a critical biomarker in gastric cancer (GC). In this study, a total of 101 GC patients underwent preoperative spectral-computed tomography (sCT) and nineteen parameters were extracted from the iodine maps of sCT by histogram analysis. The relationship between parameters derived from whole volume histogram analysis of sCT and HER-2 status of GC were further investigated. Our present results indicated that parameters derived from sCT, particularly the 99^th percentiles, could be utilized as an imaging biomarker in assessing the HER2 overexpression of GC. This founding would help Gastrointestinal Oncologists to develop an effective treatment strategy for patients with GC.