©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2024; 30(35): 3959-3964
Published online Sep 21, 2024. doi: 10.3748/wjg.v30.i35.3959
Published online Sep 21, 2024. doi: 10.3748/wjg.v30.i35.3959
Calculus bovis in hepatocellular carcinoma: Tumor molecular basis, Wnt/β-catenin pathway role, and protective mechanism
Khaled Mohamed Mohamed Koriem, Department of Medical Physiology, Medical Research and Clinical Studies Institute, National Research Centre, Giza 12622, Egypt
Author contributions: Koriem KMM performed the overall conception, design and writing of the manuscript, and the review of literature.
Conflict-of-interest statement: There is no conflict of interest.
Corresponding author: Khaled Mohamed Mohamed Koriem, PhD, Professor, Department of Medical Physiology, Medical Research and Clinical Studies Institute, National Research Centre, 33 El-Buhouth Street, Dokki, P.O. Box, Giza 12622, Egypt. kkoriem@yahoo.com
Received: July 13, 2024
Revised: August 21, 2024
Accepted: August 26, 2024
Published online: September 21, 2024
Processing time: 61 Days and 22.1 Hours
Revised: August 21, 2024
Accepted: August 26, 2024
Published online: September 21, 2024
Processing time: 61 Days and 22.1 Hours
Core Tip
Core Tip: Disturbances in lipid metabolism, cholesterol metabolism, bile acid metabolism, alcohol metabolism, and xenobiotic detoxification lead to fatty liver disease and liver cirrhosis. Dysregulation of the Wnt/β-catenin signaling pathway occurs due to liver cancer. Oleanolic acid, ergosterol, and ursolic acid are Calculus bovis (CB) ingredients with anti-primary liver cancer properties. Additionally, CB is important in the treatment of primary liver cancer through the Wnt/β-catenin pathway linked to immunity and apoptosis.