Published online Aug 28, 2024. doi: 10.3748/wjg.v30.i32.3783
Revised: August 8, 2024
Accepted: August 13, 2024
Published online: August 28, 2024
Processing time: 79 Days and 18.5 Hours
Core Tip: Autoimmune gastritis (AIG) is associated with a lower risk of gastric cancer than expected due to the low prevalence of precancerous lesions. In contrast, the risk of type 1 neuroendocrine tumors (Type1-NETs) is high and always co-exists with anti-parietal cell antibodies and extensive oxyntic atrophy. Endoscopic surveillance is needed for the early diagnosis and curative treatment of Type1-NETs. The progression of gastric atrophy during the course of AIG leads to hypochlorhydria and subsequent changes in the gastric microbiome. Among the numerous species harboring the stomach in patients with atrophic AIG, Streptococcus anginosus is one of the key candidates to be a driver of gastric carcinogenesis in post- Helicobacter pylori era.
