Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2024; 30(3): 283-285
Published online Jan 21, 2024. doi: 10.3748/wjg.v30.i3.283
Cholecystokinin and cholecystokinin-A receptor: An attractive treatment strategy for biliary dyskinesia?
Jun Chang, Yan Liu, Ting-Can Jiang, Lan Zhao, Jian-Wei Liu
Jun Chang, Lan Zhao, Tianjin Institute of Acupuncture and Moxibustion, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
Yan Liu, Department of Gastroenterology, Tianjin Hospital of Integrated Traditional Chinese and Western Medicine Nankai Hospital, Tianjin 300100, China
Ting-Can Jiang, State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Jian-Wei Liu, School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Author contributions: Chang J drafted the manuscript; Liu Y and Jiang TC edited and revised the manuscript; Zhao L and Liu JW revised the letter and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lan Zhao, MD, PhD, Professor, Researcher, Tianjin Institute of Acupuncture and Moxibustion, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Changling Road, Xiqing District, Tianjin 300381, China. lanzhao69@163.com
Received: October 28, 2023
Peer-review started: October 28, 2023
First decision: December 5, 2023
Revised: December 16, 2023
Accepted: January 9, 2024
Article in press: January 9, 2024
Published online: January 21, 2024
Processing time: 81 Days and 18 Hours
Core Tip

Core Tip: Biliary dyskinesia has an estimated 10% morbidity rate and its cause is unknown, hindering the development of appropriate treatments. Traditional surgical treatments have side effects and there is thus an urgent need to identify safe and effective therapeutic targets. This letter agrees with the findings of “Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct” and provides a brief overview of the prospects and challenges of cholecystokinin (CCK) and CCK-A receptors as potential targets in biliary dyskinesia from the perspective of animal experiments and clinical studies.