Ibrahim L, Basheer M, Khoury T, Sbeit W. Yield of alarm features in predicting significant endoscopic findings among hospitalized patients with dyspepsia. World J Gastroenterol 2024; 30(26): 3210-3220 [PMID: 39086631 DOI: 10.3748/wjg.v30.i26.3210]
Corresponding Author of This Article
Maamoun Basheer, MD, Research Scientist, Department of Gastroenterology, Galilee Medical Center, 89 Nahariya-Cabri Road, Nahariya 22001, Israel. maamon.basheer@mail.huji.ac.il
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 14, 2024; 30(26): 3210-3220 Published online Jul 14, 2024. doi: 10.3748/wjg.v30.i26.3210
Yield of alarm features in predicting significant endoscopic findings among hospitalized patients with dyspepsia
Lama Ibrahim, Maamoun Basheer, Tawfik Khoury, Wisam Sbeit
Lama Ibrahim, Department of Internal Medicine, Galilee Medical Center, Nahariya 22001, Israel
Maamoun Basheer, Tawfik Khoury, Wisam Sbeit, Department of Gastroenterology, Galilee Medical Center, Nahariya 22001, Israel
Maamoun Basheer, Tawfik Khoury, Wisam Sbeit, Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel
Author contributions: Khoury T and Sbeit W contributed to the study concept and design, and reviewed the manuscript for critical intellectual content; Ibrahim L contributed to the data collection; Ibrahim L, Basheer M, and Sbeit W wrote the first draft of the manuscript; All authors approved the final version of the manuscript to be published.
Institutional review board statement: The study protocol conforms to the ethical guidelines of the 1975 Declaration of Helsinki and was approved by the human research committee of each institution (Approval No. 0189-21-NHR).
Informed consent statement: Written informed consent was waived by the local ethical committees due to the retrospective non-interventional nature of the study.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The data are available with the corresponding author at the Gastroenterology department at Galilee Medical Center, and will be available upon reasonable request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Maamoun Basheer, MD, Research Scientist, Department of Gastroenterology, Galilee Medical Center, 89 Nahariya-Cabri Road, Nahariya 22001, Israel. maamon.basheer@mail.huji.ac.il
Received: January 13, 2024 Revised: April 29, 2024 Accepted: May 16, 2024 Published online: July 14, 2024 Processing time: 178 Days and 3.5 Hours
Core Tip
Core Tip: Dyspepsia is a common symptom complex necessitating medical consultation. Alarm features usually guide the necessity of performing upper endoscopy in the outpatient settings. Upper endoscopy and data regarding alarm features in hospitalized patients with dyspepsia are lacking. We found that tachycardia, persistent vomiting, normocytic anemia, upper gastrointestinal bleeding, leukocytosis, and hypoalbuminemia were strongly associated with significant endoscopic findings. Unexplained weight loss and abnormal computed tomography findings were strongly associated with malignancy. This is the first study exploring alarm features in hospitalized patients with dyspepsia. Our findings might guide physicians in prioritizing hospitalized patients for upper endoscopy performance.
