Reactivation of hepatitis B virus infection – an important aspect of multifaceted problem

doi:10.3748/wjg.v30.i26.3193

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Jul 14, 2024 (publication date) through Nov 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2024; 30(26): 3193-3197
Published online Jul 14, 2024. doi: 10.3748/wjg.v30.i26.3193

Reactivation of hepatitis B virus infection – an important aspect of multifaceted problem

Sergey Morozov, Sergey Batskikh

Sergey Morozov, Department of Gastroenterology, Hepatology and Nutrition, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow 115446, Russia

Sergey Batskikh, Department of Hepatology, Moscow Clinical Scientific Center N.A. A.S. Loginov, Moscow 111123, Russia

Author contributions: Morozov S and Batskikh S contributed to this paper; Morozov S and Batskikh S designed the overall concept and outline of the manuscript. All authors contributed to the discussion and design of the manuscript. All authors contributed to the writing, and editing the manuscript, illustrations, and review of literature.

Supported by Ministry of Science and Higher education of Russia, No. FGMF-2022-0005; and Moscow Healthcare Department, No. 123040700014-4.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Sergey Morozov, DSc, MD, PhD, Doctor, Senior Researcher, Department of Gastroenterology, Hepatology and Nutrition, Federal Research Center of Nutrition, Biotechnology and Food Safety, Kashirskoye Shosse 21, Moscow 115446, Russia. morosoffsv@mail.ru

Received: March 14, 2024
Revised: May 28, 2024
Accepted: June 19, 2024
Published online: July 14, 2024
Processing time: 117 Days and 5 Hours

Core Tip

Core Tip: Occult hepatitis B virus (HBV) infection is a result of previous hepatitis B (PHB) and source for reactivation of HBV. This may be a challenge when anti-cancer treatment is provided. However, PHB is a reason of other disorders, like cancer and autoimmune disorders development. We discuss this multifaceted problem from the viewpoint of pathogenetic mechanisms, and possible practical approaches.